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[ccp4bb] Opening for Scientist I/II, Protein Crystallization in AbbVie



The Structural Biology Group at AbbVie is seeking a self-motivated scientist with an innovative mindset to join the Crystallization Group in support of structure-based drug design. The ideal candidate should have extensive experience in protein crystallization and crystal handling. The candidate should have in-depth knowledge of protein _expression_, purification, and characterization techniques. They should be familiar with Laboratory Information Management System (LIMS) and comfortable working with automated crystallization instruments. The individual must be able to balance the needs of multiple projects and adjust to rapidly changing priorities. The candidate also needs to demonstrate good troubleshooting and problem-solving skillsets. 

Key Responsibilities:

  • Perform crystallization screening against various biological macromolecules, including soluble proteins, membrane proteins, protein-ligand complexes, protein-protein complexes, biologics, etc. 
  • Conduct crystal optimization and generate high quality crystals for follow-up experiments.
  • Identify cryo-protectant conditions and harvest crystals for data collection at synchrotron.
  • Actively participate in innovative solutions to improve the crystallization process.
  • Participate in new technology development.
  • Accurately record and communicate experimental results.
    Qualifications

Position will be hired based on level of education and experience.

  • Master’s degree with 2-5+ years of experience
  • Bachelor’s degree with 5-7+ years of experience
  • Proven hands-on experience in high throughput protein crystallization using robotics and LIMS
  • Knowledgeable in protein _expression_, purification, and characterization methods
  • Excellent collaboration and communication skills (oral and written)
  • Experience in a drug discovery environment is a plus
  • Experience in fragment-based drug discovery is a plus
  • Experience with Cryo-EM, MicroED or SAXS is a plus

Please apply online
AbbVie careers, Req ID 2101400






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