Postdoctoral positions in integrative structural
biology study of signaling complexes

The Page Laboratory at the University of Connecticut
Health Center has an immediate opening for up to two postdoctoral candidates to study eukaryotic signaling enzymes, with a focus on the function of phosphatases that form large signaling complexes and phosphatase drug/inhibitor development (recent publications
include Nature [https://www.nature.com/articles/s41586-023-06870-3], Nature communications [https://www.nature.com/articles/s41467-023-37372-5]). 

All studies combine cryo-EM, NMR and/or X-ray crystallography
with biochemical and cellular experiments, allowing postdocs to augment their training in those techniques that are new. Applicants with strong backgrounds in biochemical techniques, and especially eukaryotic protein expression and protein crystallization
or cryoEM, are encouraged to apply.

The Page laboratory is housed in a newly renovated ~250,000 sq. ft. research
laboratory in Farmington, CT. The laboratories are open-lab-space facilities and allow close interaction with the adjunct structural biology and molecular/cell biology groups at UConn Health. The Page laboratory is equipped with all necessary infrastructure
to produce (E. coli, mammalian, insect), purify and analyze protein and protein complexes (ITC, SPR etc.) and crystallization robotics for crystal production (Art Robbins Gryphon LCP nano-liter crystallization robot; Art Robbins CrysCam) as well as all needed
equipment for cryo-EM sample preparation and data evaluation.

UCHC facilities include a Bruker Venture D8 system
(IμS Diamond source) with a Photon III M14 detector and cold stream is available for crystal screening and data collection for in-house data collection, synchrotron access at NSLS-II, SSRL, Diamond and high-field NMRs (Bruker Avance Neo 600 MHz and 800 MHz
NMR spectrometers). Cryo-EM instrument includes a TFS Vitrobot IV and a TFS Tundra/Falcon C) that allows for rapid screening of auto-grid/clipped samples of sample conditions. Access to Krios instruments for data collection is readily available.

UCHC has a welcoming, collaborative and vibrant
environment for structural, biochemical and translational research. Farmington, CT, is located in New England between Boston (90 min.) and New York City (90 min).
Laboratory alumni are successful, including alums that have their own academic
faculty positions, are directors/chief scientists in pharma and startups, gone into public policy, among others.

Starting date, salary and project details are very
competitive and negotiable. 

Please e-mail a Cover Letter and CV to Rebecca Page
(rpage@uchc.edu)