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Postdoctoral Positions in:

1)   Structural biology of ion channel assembly mechanisms

2)   Structural studies and protein design of toxin sponge
proteins

MINOR LAB
UCSF –
Cardiovascular Research Institute

Multiple postdoctoral positions
are available immediately for highly motivated individuals with strong backgrounds
in biophysics, biochemistry, structural biology, or computational methods, and
an interest in structural biology of ion
channel assembly mechanisms or structural studies and protein design of
toxin sponge proteins in the lab of Prof. Dan Minor at the University of California, San
Francisco (UCSF). The
Minor Lab merges structural, biochemical, chemical biology, genetic, and
electrophysiological methods to dissect mechanisms of complex protein machines
involved in electrical signaling and to uncover mechanisms of toxin resistance
in poison organisms.

1)    Structural
biology of ion channel assembly

Projects focus on cryo-EM and other approaches
to study the structural principles of ion channel assembly and interactions
with chaperones. Candidates should have (or expect) an Ph.D. or M.D. and should
have demonstrated achievements in protein biochemistry or biophysics, X-ray
crystallography, cryo‑electronmicroscopy, or electrophysiology.
Computational skills are also highly desired.

Ongoing work is represented by:

Arrigoni, C., Lolicato, M., Shaya, D., Rohaim,
A., Findeisen, F., Fong, L.-K., Colleran, C.M., Dominik, P., Kim, S.S.,
Schuermann, J., DeGrado, W.F., Grabe, M., Kossiakoff, A.A., and Minor, D.L., Jr.

‘Quaternary structure independent folding of voltage-gated ion
channel pore domain subunits’ 

Nature Structural and Molecular Biology 29 537-548
(2022)  https://wsww.nature.com/articles/s41594-022-00775-x 

Chen, Z., Mondal, A.,
Abderemane-Ali, F., Montano, J., Zaro, B., and Minor, D.L., Jr.,

’EMC holdase:Ca_V1.2/Ca_Vβ₃ complex
and Ca_V1.2 channel structures reveal Ca_V assembly
and drug binding mechanisms’ bioRxiv https://www.biorxiv.org/content/10.1101/2022.10.03.510667v1

2)    Structural
studies and protein design of toxin sponge proteins

This project focuses on using structural
biology, protein engineering, computational design, and molecular evolution to characterize
and develop new toxin sponge proteins. Candidates should have (or expect) an
Ph.D. or M.D. and should have demonstrated achievements in protein structure
analysis, protein biophysics, computational methods, or selection methods.
Computational skills are highly desired.

Ongoing work
is represented by:

Yen, T.-J., Lolicato, M.,
Thomas-Tran, R., Du Bois, J., and Minor,
D.L., Jr.,

Chen, Z., Zakrzewska, S., Hajare, H., Alvarez-Bullya, A., 
Abderemane-Ali, F., Bogan, M., Ramirez, D., O’Connell, L.A., Du Bois, J., and Minor,
D.L., Jr.

‘Definition of a saxitoxin (STX) binding code enables discovery
and characterization of the Anuran saxiphilin family’ Proceedings
of the National Academy of Sciences, USA (in press) and bioRxiv https://www.biorxiv.org/content/10.1101/2022.06.09.495489v1

More information is available at the lab website http://www.cvri.ucsf.edu/~dminor/

Fellows
will benefit from both the outstanding lab environment and the highly
collaborative UCSF community.

TO APPLY: Interested individuals
should send a current CV to Prof. Daniel Minor at daniel.minor@ucsf.edu

 @ElectrosomeUCSF

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