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Postdoctoral Positions in:

1)   Structural biology of ion channel assembly and chaperone
interactions

2)   Structural studies and protein design of toxin sponge
proteins

MINOR LAB
@UCSF – Cardiovascular
Research Institute

Multiple postdoctoral positions
are available immediately for highly motivated individuals with strong backgrounds
in biophysics, biochemistry, structural biology, or computational methods, and
an interest in structural biology of ion
channel assembly mechanisms or structural studies and protein design of
toxin sponge proteins in the lab of Prof. Dan Minor at the University of California, San
Francisco (UCSF). The
Minor Lab merges structural, biochemical, chemical biology, genetic, and
electrophysiological methods to dissect mechanisms of complex protein machines
involved in electrical signaling and to uncover mechanisms of toxin resistance
in poison organisms.

1)    Structural
biology of ion channel assembly

Projects focus on cryo-EM and other approaches
to study the structural principles of ion channel assembly and interactions
with chaperones. Candidates should have (or expect) an Ph.D. or M.D. and should
have demonstrated achievements in protein biochemistry or biophysics, X-ray
crystallography, cryo‑electronmicroscopy, or electrophysiology.
Computational skills are also highly desired.

Ongoing work is represented by:

Arrigoni, C., Lolicato, M., Shaya, D., Rohaim,
A., Findeisen, F., Fong, L.-K., Colleran, C.M., Dominik, P., Kim, S.S.,
Schuermann, J., DeGrado, W.F., Grabe, M., Kossiakoff, A.A., and Minor, D.L., Jr. ‘Quaternary structure
independent folding of voltage-gated ion channel pore domain subunits’ 
Nature Structural and Molecular
Biology 29 537-548
(2022)  https://wsww.nature.com/articles/s41594-022-00775-x 

Chen, Z., Mondal, A.,
Abderemane-Ali, F., Montano, J., Zaro, B., and Minor, D.L., Jr.,

’EMC holdase:Ca_V1.2/Ca_Vβ₃ complex
and Ca_V1.2 channel structures reveal Ca_V assembly
and drug binding mechanisms’ bioRxiv https://www.biorxiv.org/content/10.1101/2022.10.03.510667v1

2)    Structural
studies and protein design of toxin sponge proteins

This project focuses on using structural
biology, protein engineering, computational design, and molecular evolution to characterize
and develop new toxin sponge proteins. Candidates should have (or expect) an
Ph.D. or M.D. and should have demonstrated achievements in protein structure
analysis, protein biophysics, computational methods, or selection methods.
Computational skills are highly desired.

Ongoing work
is represented by:

Yen, T.-J., Lolicato, M.,
Thomas-Tran, R., Du Bois, J., and Minor,
D.L., Jr.,

Chen, Z., Zakrzewska, S., Hajare, H., Alvarez-Bullya, A., 
Abderemane-Ali, F., Bogan, M., Ramirez, D., O’Connell, L.A., Du Bois, J., and Minor,
D.L., Jr. ‘Definition of a saxitoxin (STX)
binding code enables discovery and characterization of the Anuran saxiphilin
family’ Proceedings of the National Academy of Sciences, USA 119 e2210114119
(2022) https://www.pnas.org/doi/10.1073/pnas.2210114119

More information is available at the lab website http://www.cvri.ucsf.edu/~dminor/

Fellows
will benefit from both the outstanding lab environment and the highly
collaborative UCSF community.

TO APPLY: Interested individuals
should send a current CV to Prof. Daniel Minor at daniel.minor@ucsf.edu