Our group has up to two openings for postdoctoral fellows to be funded on a Cancer Research UK programme aimed at understanding lysosomal control of cell proliferation and stress responses in cancer cells. The programme involves cryo-electron microscopy, X-ray crystallography, H/D exchange mass spectrometry, as well as other biophysical and biochemical approaches.
These posts will focus on the reconstitution of large signalling assemblies that detect nutritional and stress signals on and off membranes. The candidate will join a vibrant team of researchers investigating structures, regulation, kinetics and dynamics of phosphoinositide 3-kinase family members reconstituted with their regulators on membrane surfaces. This programme concerns regulation of lipid kinase VPS34 and protein kinase mTOR and ATM-containing complexes. The research combines biochemical, biophysical and cell biological methods with structural approaches. This is a unique opportunity to play a major role in exciting programme, introduce new ideas, and disseminate research results, while working in a collaborative and supportive environment.
The position is available immediately, with an application closing date of 26 August 2021.
For more details, please see
https://mrc.tal.net/vx/mobile-0/appcentre-ext/brand-3/candidate/so/pm/4/pl/1/opp/1625-Postdoctoral-Scientist-PNAC-Dr-Roger-Williams-LMB-1625/en-GB
Roger Williams
Dr. Roger Williams, FMedSci, FRS
rlw@mrc-lmb.cam.ac.uk
MRC Laboratory of Molecular Biology
Francis Crick Avenue
Cambridge CB2 0QH
UK
Phone: +44 1223 267094
Roger Williams
rlw@mrc-lmb.cam.ac.uk