Dear all,
The Brian Baker laboratory at the University of Notre Dame is looking for highly motivated postdoctoral fellows to join the structural immunology lab. The lab focuses on the intersection of protein structural biology, molecular biophysics, and molecular recognition and signaling in cellular immunity. Research in the laboratory blends molecular immunology with X-ray crystallography, biochemistry, and biophysics, and computational modeling, design, and simulation.
Big picture questions address fundamental mechanisms of immune recognition as well as cancer immunology and immunotherapy, autoimmunity and transplantation immunology, and T cell-based vaccine design and optimization. The laboratory is highly collaborative, working with experts in immunology and biophysics across the world, offering a tremendous opportunity for cross-disciplinary training.
Currently available projects center around:
•Understanding, predicting, and manipulating T cell receptor specificity and cross-reactivity using combined experimental and in silico approaches.
https://pubmed.ncbi.nlm.nih.gov/30224695/ https://pubmed.ncbi.nlm.nih.gov/30617019/
•Understanding the structural and physical rules that distinguish normal from abnormal immune recognition, such as autoimmunity and transplant rejection.
https://pubmed.ncbi.nlm.nih.gov/28572406/
•Identifying the structural and physical features that promote T cell recognition of cancer neoantigens to improve the design of T cell-based vaccines.
https://pubmed.ncbi.nlm.nih.gov/32807968/
https://pubmed.ncbi.nlm.nih.gov/31555277/
Applicants with strong backgrounds and accomplishments in structural biology, structural modeling, and/or protein biophysics are welcome. Experience in mammalian cell culture is a strong plus. Familiarity with immunology is strongly preferred; in its absence, unbridled enthusiasm for learning how structure and biophysics impact immunology can substitute. Strong applicants with backgrounds in T cell immunology interested in developing as structural biologists are also welcome.
Interested applicants should contact Brian Baker at brian-baker@nd.edu or via Twitter at @ND_BakerLab. Visit the lab website at www.bmblab.org.
Please see the attached flyer for additional information about the lab and the positions.
Sincerely,Nishant K. Singh, PhD
HHMI Research Associate at Ragon Institute of MGH, MIT, and Harvard
Postdoctoral Fellow at Koch Institute for Integrative Cancer Research of MIT
nksingh@mit.edu
NSINGH0@mgh.harvard.edu