Postdoctoral
Position: Structural biology of the actin cytoskeleton
Djinovic lab is interested in
the molecular mechanisms underlying the architecture and
assembly of the actin based cytoskeleton.
This project focuses
on ubiquitous human proteins
α-actinin-1 and -4, which self-associate to form a homo- and
hetero dimeric units that cross-link actin filaments in
calcium-regulated manner. The project is jointly funded by
Austrian and Slovene Science Funds and is a close collaboration
between Djinovic group at Vienna, Austria, and Pavsic group at
University of Ljubljana, Slovenia. The two young and dynamic
groups will join forces to understand the detailed molecular
mechanism of regulation
of this essential F-actin crosslinking protein by calcium and
specific phosphoprylation events.
We employ an integrated approach by
combining biochemistry, cell,
chemical and structural biology approaches, including X-ray
crystallography, small angle scattering and (starting) cryo-EM.
The successful candidates will be involved in all aspects of the
project, including protein expression, purification,
biophysical, biochemical characterization and integrative
structural biology.
Qualifications and
experience: The applicants should hold
a PhD degree in a relevant field and two years of post-doctoral
experience in a structural biology lab. Strong background in
molecular cloning, expression, and purification of protein
complexes is essential. Prior knowledge of crystallography
and/or single-particle electron microscopy is needed. Excellent
spoken and written English are required.
The successful applicants
will work in a stimulating scientific environment: Department for Structural and
Computational Biology at Max Perutz Labs, a joint venture between
University of Vienna and Medical University of Vienna. The Labs
are located at Vienna BioCenter, the largest molecular
life science hub in Austria. We are equipped equipped with state-of-the-art
research infrastructure for
experimental and computational work, and have access to
facilities at Vienna Biocenter Core Facilities, which includes
mass-spectrometry, a blend of Protein technologies and electron
microscopy instruments (Glacios, Krios). The group has in
addition access to cryo-EM Titan-Krios through BAG at ESRF and
to major European synchrotron high-brilliance X-ray sources.
1. A concise description of
research experience, including a
list of published peer-reviewed articles.
2. Copy of the PhD
diploma (or equivalent).
3. Contact details
for three references, of which one should be your PhD
supervisor.
Please prepare the application as a single package
in PDF format, and send it to <admin.vbc5@univie.ac.at>, subject Postdoctoral
position in Djinovic Lab.
Further information can be
obtained from Kristina Djinovic Carugo kristina.djinovic@univie.ac.at.
Closing date: review of applications
begins immediately and will continue until the position is
filled.
WEB-PAGES
https://www.maxperutzlabs.ac.at/research/research-groups/djinovic
https://www.maxperutzlabs.ac.at/
https://structbio.univie.ac.at/
https://structbio.univie.ac.at/research-infrastructure-facilities/
https://www.viennabiocenter.org/
https://www.viennabiocenter.org/facilities/
-- Department of Structural and Computational Biology Max Perutz Labs University of Vienna Campus Vienna Biocenter 5 A-1030 Vienna Austria e-mail: kristina.djinovic@univie.ac.at Phone: +43-1-4277-52203 Phone: +43-1-4277-52201 (secretary) Mobile A: +43-664-817 5259 Fax: +43-1-4277-9522
-- Department of Structural and Computational Biology Max Perutz Labs University of Vienna Campus Vienna Biocenter 5 A-1030 Vienna Austria e-mail: kristina.djinovic@univie.ac.at Phone: +43-1-4277-52203 Phone: +43-1-4277-52201 (secretary) Mobile A: +43-664-817 5259 Fax: +43-1-4277-9522