Dear All,

 

Applications are invited
for a joint postdoctoral scientist position in the laboratories of Dr. Sarah
Heissler and Dr. Krishna Chinthalapudi at the Ohio State University. The
research project focuses on understanding the role of myosin motors and other
cytoskeletal proteins in health and disease. We combine state-of-the-art structural
biology approaches including X-ray crystallography and cryo-EM with biochemical,
biophysical and cell biological methods to investigate how protein structure is
related to its function. Our laboratories are equipped with state-of-the-art
instrumentation for the proposed studies and have generous access to a Titan
Krios G3i Cryo-TEM equipped with a bioquantum imaging filter and a K3 direct
electron detector, imaging phase plates, STEM/TEM tomography, and an image
spherical aberration corrector. In addition, our labs have access to a Glacios with
a falcon III detector and Ceta-D camera for MicroED analysis at the world-class
Center for Electron Microscopy and Analysis (CEMAS) at the Ohio State
University.

 

Selected examples of our work include:

 

Heissler SM, Arora AS, Billington N, Sellers JR,
Chinthalapudi K. Cryo-EM structure of the autoinhibited state of myosin-2. Sci
Adv. 2021 Dec 24;7(52):eabk3273. doi: 10.1126/sciadv.abk3273.

 

Chinthalapudi K, Heissler SM, Preller M, Sellers
JR, Manstein DJ. Mechanistic insights into the active site and allosteric
communication pathways in human nonmuscle myosin-2C. Elife. 2017 Dec
19;6:e32742. doi: 10.7554/eLife.32742.

 

Candidates must have (or
will be shortly awarded) a Ph.D. degree and strong practical experience in
biochemistry and structural biology. Experiences with molecular biology
techniques, protein expression and purification, cell biology and/or
high-resolution imaging are desirable.

 

For more information, please contact us and/or
visit our lab websites.

 

https://medicine.osu.edu/find-faculty/non-clinical/physiology-and-cell-biology/sarah-heissler

 

https://medicine.osu.edu/find-faculty/non-clinical/physiology-and-cell-biology/krishna-chinthalapudi

 

To be considered for this position, please email
your curriculum vitae, a short cover letter with research experience and
interests and contact information for three references to Sarah Heissler (sarah.heissler@osumc.edu) and Krishna Chinthalapudi (krishna.chinthalapudi@osumc.edu).

 

Thank you,

Sarah & Krishna