Our team “Nuclear receptors as integrators of endogenous and environmental signals” (https://www.cbs.cnrs.fr/index.php/en/home-equipea5) has an opening for a 2-year postdoctoral research fellow funded by the French National Research Agency.
Project
A number of compounds present in the environment act as endocrine
disruptors and cause adverse effects in humans and wild-life by
interfering with the normal signaling of various cellular targets.
Mounting data suggest a link between the increasing exposure to these
chemicals and the development of diseases including reproduction
defects, hormone-related cancers, or metabolic disorders. Our team is
using a battery of structural, biophysical and cell-based approaches to
provide a rational framework for better understanding and combating the
impact of environmental pollutants on human health. The position
requires the applicant to work on structural and biochemical
characterization of various receptors including the peroxisome
proliferator activated receptor γ (PPARγ), the pregnane X receptor (PXR)
and the aryl hydrocarbon receptor (AHR).
Qualifications
Applicants must hold a PhD in biological sciences (preferably in
biochemistry or structural biology), and should have a strong background
in protein expression and purification, cryogenic electron microscopy
and/or X-ray crystallography.
Anticipated starting date:
1st of September 2024
Application
The application, including CV, motivation letter and 2 reference letters, should be sent to William Bourguet (william.bourguet@cbs.cnrs.fr)
Recent publications of the team in the field:
– Kwong HS, et al. Structural insights into the activation of human Aryl
Hydrocarbon Receptor by the environmental contaminant benzo[a]pyrene
and structurally related compounds. J Mol Biol. 2023 Dec 20:168411.
– Gruszczyk J, et al. Cryo-EM structure of the agonist-bound
Hsp90-XAP2-AHR cytosolic complex. Nat Commun. 2022 Nov 16;13(1):7010.
– Delfosse V, et al. Mechanistic insights into the synergistic
activation of the RXR-PXR heterodimer by endocrine disruptor mixtures.
Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2020551118.
Best wishes.
—
William Bourguet
Nuclear receptors as integrators of endogenous and environmental signals
Center for Structural Biology
CNRS UMR5048 / INSERM U1054 / UM
29 rue de Navacelles
34090 Montpellier, France
Phone: 33 4 67 41 7702
Fax: 33 4 67 41 7913
http://www.cbs.cnrs.fr/index.php/en/home-equipea5
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