Join Us | COLLABORATIVE DUBLIN-DUNDEE

POSTDOCTORAL FELLOW (3 years)

Structural and functional aspects of membrane trafficking linked to LRRK2 phosphorylation
of Rab GTPases

Closing Date: 30 Apr 2025

Salary: 
€43,907 – €51,677

 

Background

The most common familial and sporadic cases associated with Parkinson’s disease involve the Ser/Thr kinase LRRK2.
The substrates of LRRK2 are a group of Rab GTPases that control diverse aspects of cellular dynamics including autophagy, exocytosis, ciliogenesis, and vesicle motility. Collaborative efforts from the labs of Amir Khan (Dublin, Ireland) and Dario Alessi (Dundee,
Scotland) have identified several potentially exciting new protein complexes that may link LRRK2 activity to the molecular defects seen in Parkinson’s Disease. This project will involve the purification and structural characterization of protein complexes,
as well as functional studies to understand how these complexes regulate membrane trafficking. Outstanding in-house resources at Dublin and Dundee include protein production facilities, biophysical instrumentation (ITC, SPR, light scattering), and access to
mass spectrometry at the MRC PPU. In addition there is generous beamtime available at synchrotrons, as well as cryo-electron microscopy facilities. For further reading see PMID 34580980, 32017888, and 38091401. The Khan lab is funded through Research Ireland
and the Michael J Fox Foundation.

Requirements

The employment will be based in Dubin, Ireland. Candidates are expected to have experience in recombinant protein
expression/purification and expertise in either X-ray structure determination or cryo-electron microscopy. Although Dublin-based, candidates are expected to be mobile and perform experiments in Dundee, Scotland, as needed during the term of the fellowship.

PDF salary and start date

The gross salary for the fellow position ranges from €43,907 – €51,677 depending on the level of experience. The
position is available immediately, or at the very latest, June 1, 2025, and is funded for 3 years.

Further Information

Amir Khan (Amir.Khan@tcd.ie), School of Biochemistry and Immunology, Biomedical
Sciences Institute, Trinity College Dublin, Dublin 2, Ireland

Application Procedure

As a single PDF file, please submit a motivation letter, Curriculum Vitae, and email/phone information for two referees
to: Amir.Khan@tcd.ie