Dear all,

 

We have 3 postdoctoral positions available
in my group at the Novo Nordisk
Foundation Center for Protein Research, University of Copenhagen. We aim to recruit scientists with extensive experience in one or more of the techniques of interest to help pioneer and establish this new research field. The positions are for 2 years in the
first instance and can be renewed for up to 4 years in total, providing a unique long-term opportunity to work on an exciting project in a well-equipped and supportive environment.

Background
Bacteria are under constant attack by bacteriophages, and have evolved intricate systems to tackle this constant threat (Doron et al, Science, 2018). We have a special focus on
anti-bacteriophage defense at
the bacterial cell envelope/membrane, for which we recently received a large Hallas Møller Ascending Investigator grant from the Novo Nordisk Foundation. We have been actively working on
anti-bacteriophage defense in
the past years with our first preprint now online
(Hu et al.,
https://www.biorxiv.org/content/10.1101/2023.12.18.572097v1).

We will investigate defense systems using three approaches: single particle cryo-EM, cryo-electron tomography, and protein bioinformatics/design. Together with
expert collaborators in phage biology, engineering and light microscopy, we aim to unravel fundamentally novel mechanisms in
anti-bacteriophage defense and
biology.

We are looking for three motivated postdocs with experience in one of the three approaches to help tackle this exciting challenge.

Position 1
The postdoc will be involved in the expression and purification of components of anti-bacteriophage defense systems interacting with the bacterial cell membrane. Using single particle cryo-electron microscopy, the postdoc will investigate the structure of these
systems in different states.

Position 2
The postdoc will study anti-bacteriophage defense systems interacting with the bacterial cell membrane using cryo-electron tomography. They will investigate how the defense systems are able to ward of bacteriophage infections.

Position 3
The postdoc will investigate anti-bacteriophage defense systems as well as phage-encoded inhibitors for these defense systems from a computational point of view. In particular, they will use structure prediction to predict novel defense systems and protein
design to design new defense systems.

 More info and apply here (deadline
: January 8 2024, 23.59pm CET):

https://employment.ku.dk/faculty/?show=160758

If you have any questions about the positions, please contact: nicholas.taylor@cpr.ku.dk.

Best wishes,

 

Nicholas