Applications from highly qualified candidates are invited for postdoctoral positions in my lab at the University of South Alabama in Mobile, AL. There are several NIH-funded projects: One is an ongoing project to elucidate molecular mechanisms underpinning the cephalosporin resistance of Neisseria gonorrhoeae conferred by mutated penicillin-binding protein 2 (PBP2). Another is a structure/function analysis of PlzA, a cyclic-di-GMP binding protein from the Lyme disease spirochete, Borreliella burgdorferi, to understand its biological roles in the enzootic cycle of the pathogen. Finally, there is a project to develop a lead compound against familial hypercholesterolemia.

Projects entail site-directed mutagenesis, cloning, purification and crystallization of proteins, collecting diffraction data, solving structures by X-ray crystallography, and various biophysical techniques (ITC, fluorescence spectroscopy). Investigations using cryo-EM are also planned.

Qualifications: Candidates should hold a PhD in biochemistry or chemistry, with a strong background in molecular biology and protein crystallography. For the PBP2 project, experience with enzyme kinetics is preferred.

To apply: Please send cover letter and CV directly to me by email to cdavies@southalabama.edu. Informal enquiries by email are welcome.

 

Christopher Davies, Ph.D.

Professor, Dept. of Biochemistry & Molecular Biology

5795 USA Drive N, CSAB 234

University of South Alabama

Mobile AL 36688