The Protein Structure and Function Program at the Princess Margaret Cancer Centre, 

University Health Network, Toronto, Canada, has an opening for a postdoctoral fellow with experience in

macromolecular biochemistry and biophysics. 

The laboratory is interested in cancer mechanisms and development of therapeutics, 

with strong emphasis on RAS oncogenic signaling pathways as well as other cellular pathways including 

calcium signaling and ion channel regulation. To develop a better understanding of cancer, we combine 

a broad variety of approaches, which include structural biology techniques (NMR, X-ray and cryoEM),

biophysical/biochemical techniques, and tumour cell biology. The lab has access to state-of-theart

research instruments (including 800/700/600-MHz NMR, Titan-Krios and Talos cryoEM) and

many other core facilities at the Princess Margaret Cancer Centre, University of Toronto, and

other affiliated research hospitals. 

Our projects attract many local, national, and international collaborations to address biologically interesting and 

clinically relevant research questions in cancer. Princess Margaret offers an exciting and innovative research 

environment which promotes collaborations between basic and clinical researchers. The laboratory is located in the

vibrant city centre, within the MaRS complex of the Toronto Discovery District, adjacent to the downtown 

University of Toronto campus.

We are looking for an enthusiastic candidate with strong technical, organizational, and problemsolving

skills. A successful candidate will be involved in our ongoing studies on RAS pathways or

calcium signaling and s/he will enjoy working as part of a team to tackle challenging projects in

the field of cancer biology.

More detailed information about Dr. Ikura’s research can be found:

http://nmr.uhnres.utoronto.ca/ikura/index.html

Qualifications

• PhD received within the past 2 years in a related field, with strong background in

structural biology, biochemistry, biophysics, or structure-guided drug discovery.

• Knowledge of recombinant protein expression, purification and characterization is

essential.

• Experience with cell signaling proteins and structural biology would be an asset.

How to apply

Please submit a CV, one-page brief research statement, a copy of your most relevant paper, and

the names, email addresses, and phone numbers of three references to mitsu.ikura@uhnresearch.ca. 

All documents should be provided in PDF format.

Mitsu Ikura, Ph.D. Senior Scientist and Professor

Princess Margaret Cancer Centre, University Health Network

Department of Medical Biophysics, University of Toronto