Within the framework of the Collaborative Research Center 900 and the ‘COVID-19 Forschungsnetzwerk Niedersachsen’ (COFoNi) we invite applications for a
Postdoctoral research associate
to work in the group of Thomas Krey, Institute of Biochemistry at the Universität zu Lübeck (UzL; Germany). We are mainly interested in the biochemical and structural characterization of viral glycoproteins
and their roles during the viral replication cycle (mainly virus entry and interaction with the host’s immune system). The major scientific focus will be initially the glycoproteins of the Hepatitis C virus and the β-Coronavirus spike protein. The project
will actively build on our previous experience with the structural and functional characterization of glycoproteins (e.g., Fedry et al., Cell, 2017; Fedry et al., PLoS Biol, 2018; Krey et al., PLoS Path, 2013; Meola et al., J Virol, 2015; Vasiliauskaite et
al., mBio, 2017).
The position is available for an initial period of 19 months with a possibility to be extended.
We:
• Are fascinated by viral glycoproteins and their interactions with neutralizing antibodies
• Are structural biologists with a special interest in immune profiling of human antibody repertoires and single cell sequencing of human B cells
• Use a wide range of methodologies including but not limited to protein biochemistry, X-ray crystallography, cryo electron microscopy
and single cell Next Generation Sequencing (NGS)
• Offer state-of-the-art equipment in protein expression, purification and crystallization
• Provide an international, interdisciplinary, exciting and stimulating scientific environment at the UzL
• Have access to
– Ample beamtime at third generation synchrotron X-ray sources
– The cryo-EM facility at CSSB Hamburg with high-end cryo electron microscopes
– A state-of-the-art FACS facility on-campus with single-cell sequencing instrumentation
– Excellent biophysical instrumentation (Surface Plasmon resonance, SEC-MALLS, Nanoliterplate based DLS, ITC)
You:
• Have a PhD in structural biology, biochemistry, virology or a related scientific area
• Are interested in neutralizing antibodies either as therapeutic tool or as basis for informed vaccine design
• Have experience in protein purification, structural biology techniques (preferably X-ray crystallography), antibody biology or immune repertoire profiling
• Enjoy working both on your own and as part of an international and interdisciplinary team
• Like to visit international conferences and present your data
• Are a creative and enthusiastic individual committed to solve problems
Please send a cover letter, CV, relevant certificates as well as names, e-mail addresses and telephone numbers of at least two references in a single PDF to Thomas Krey (krey.thomas@mh-hannover.de).
Additional information can be provided upon request.
Prof. Dr. Thomas Krey
Hannover Medical School
Institute of Virology
Structural Virology Group
Carl-Neuberg-Str. 1
D-30625 Hannover
phone: +49 (0) 511 – 532 4308
email: krey.thomas@mh-hannover.de