ModeX Therapeutics is seeking a highly
skilled and motivated scientist to support biologics production, characterization,
and optimization for developing innovative biotherapeutics. This is an exciting
opportunity to be part of a cross-functional team and contribute to the
development of next-generation biological therapeutics in a fast-paced, rapidly
growing biotech company with a bold vision. 

Company

ModeX Therapeutics, a subsidiary of OPKO
Health, is a biotech based in Massachusetts dedicated to the concept of
modulating multiple disease targets with innovative multi-targeting strategies.
It was founded by Dr. Elias Zerhouni and Dr. Gary J. Nabel in 2020 with a team
of scientists with proven track record from early research to clinical
development, regulatory approvals, and commercialization. ModeX is pursuing the
development of novel immune-oncology therapeutics for cancers and biotherapeutics
against infectious disease.

Major responsibilities

·        
Interact closely and be part of
interdisciplinary biologics research teams to drive the discovery of innovative therapeutic antibodies and the
optimization of their biochemical and biophysical properties.

·        
Contribute to ModeX’s multi-targeting
strategy through structure-based antibody design, production, and
characterization platforms.

·        
Develop a high-throughput
antibody expression and purification platform and lead the effort in producing high-quality
multispecific antibodies for developability assessment and PK/PD studies.

·        
Perform biochemical and
biophysical characterization of diverse biologics molecules, including
multi-specifics, fusion proteins, and non-viral particle to support lead
candidate selection, focusing on antibody’s
biophysical properties including chemical stability, solubility,
polyspecificity and polyreactivity.

·        
Interpret results and present/communicate
with cross-functional colleagues for successful execution and completion of
projects.

·        
Stay
scientifically current and contribute to the implementation of new technology
and instrumentation.

·        
Ensure effective and
timely documentation in electronic laboratory notebooks.

Qualifications

·        
PhD or MS in biochemistry,
structure biology, biomedical engineering, or other life science disciplines

·        
Minimum of 3 years (PhD)/
6 years (MS) of relevant experiences

·        
Knowledge in antibody
structure and the development of antibody-based biotherapeutics is preferred.

·        
Skilled in protein expression
in mammalian cells and protein purification using various chromatography
methods and instruments such as AKTA FPLC.

·        
Experience with protein
analytic techniques such as
HPLC/UPLC, cIEF/CE-SDS, SLS/DLS, and BLI/SPR based protein-protein interaction
characterization is a plus.

·        
Excellent written and
oral communication, organization, and data analysis skills.  Outstanding troubleshooting and problem-solving
skills.

·        
Highly adaptable to a
fast-paced work environment and capable to work both independently and
collaboratively within project teams.

To apply, please send cover letter and CV
to hao.chen@Modextx.com and careers@ModeXTX.com