Dear CCP4 Community,

I am writing on behalf of the DiffUSE Project to advertise two positions that we are actively hiring for. The DiffUSE Project is a Radial program as part of Astera Institute. We are an ambitious initiative designed to unlock our understanding of protein dynamics at scale by strengthening experimental methods, computational models, and global infrastructure. Thanks in advance for circulating these to your colleagues.

For additional information, please see the job postings or reach out to diffuse@radial.org.

For full consideration, please apply with a resume or CV at the links below. Both positions are in-person at our Emeryville, CA headquarters.

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Scientist – Ensemble Structural Informatics @ Astera Institute

The position involves architecting the foundational infrastructure alongside dedicated software engineers. Duties will also include building and socializing community standards to make dynamic structural biology data as accessible, reliable, and scientifically impactful as the Protein Data Bank has been for static structures. Your work will be central to evolving alongside algorithmic advances while upholding the highest standards of scientific rigor and reproducibility.

Apply here: https://jobs.ashbyhq.com/astera/c68cd9fd-59fb-4d0f-bf56-4b7d1b2e1e90

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Scientist – Structural Biology Machine Learning @ Astera Institute

This role sits at the intersection of generative modeling and experimental structural biology. You would develop algorithms that treat experimental observables (e.g., electron density, structure factors, diffraction patterns) as direct training inputs to improve the fitting of dynamic structural biology models, design evaluation frameworks to assess them, and work closely with structural biologists and biophysicists who generate the data. We are looking for someone who is comfortable with physics-constrained learning or inverse problems, and looking to join an ambitious team to improve our models and understanding of dynamics.

Apply here: https://jobs.ashbyhq.com/astera/32822f0a-63d3-4825-8340-f8037fa16953

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All the best,

Andy Burnim, PhD

Project Manager, DiffUSE

Astera Institute | Radial