We are seeking a motivated scientist to join our team to use artificial
intelligence (AI) based methods to design novel proteins with therapeutic
potential as well as to experimentally validate and characterize the designed
proteins. The project is funded by Worldwide Cancer Research and aims to
target regulatory sites in a well-known cancer target, known to efficiently and
selectively inhibit cancer cell invasion.

The candidate will be based at the Margarita Salas Center for Biological
Research (CIB-CSIC) in Madrid. She/He will work in a multidisciplinary and
international team with experience in structural biology of the target (Lietha
Lab, CIB-CSIC, Spain) [1], AI based protein design (Baker Lab, University of
Washington, USA) [2] and relevant cancer models (Frame Lab, Cancer
Research UK Edinburgh Centre) [3]. The candidate should have experience in
computational structural biology, while experience with experimental
biochemistry and/or structural biology techniques will be a plus.

We offer:

• Working on an exciting project with therapeutic potential, using state of the
  

  art computational and experiential approaches
  

• Access to high-end computational, biochemistry and structural biology
  

  infrastructure
  

• A vibrant, multi-disciplinary and international working environment
  

• The opportunity to be part of a multidisciplinary Research Centre of the

  Spanish Research Council that successfully combines basic and applied

  research

• Situated in one of Europe’s cultural capitals

  To express your interest and send your CV or to find out more, please contact
  Daniel Lietha (daniel.lietha@cib.csic.es). All enquiries and applications will be
  treated confidentially.

  References:

1. Acebrón I, Righetto RD, Schoenherr C, de Buhr S, Redondo P, Culley J,

   Rodríguez CF, Daday C, Biyani N, Llorca O, Byron A, Chami M, Gräter F,
   Boskovic J, Frame MC, Stahlberg H, Lietha D. Structural basis of Focal Adhesion
   Kinase activation on lipid membranes. EMBO J 39, e104743 (2020).

2. Watson JL, Juergens D, Bennett NR, Trippe BL, Yim J, Eisenach HE, Ahern W,
   Borst AJ, Ragotte RJ, Milles LF, Wicky BIM, Hanikel N, Pellock SJ, Courbet A,
   Sheffler W, Wang J, Venkatesh P, Sappington I, Torres SV, Lauko A, De Bortoli
   V, Mathieu E, Ovchinnikov S, Barzilay R, Jaakkola TS, DiMaio F, Baek M, Baker
   D. De novo design of protein structure and function with RFdiffusion. Nature 620,
   1089-1100 (2023).

3. M, Dawson JC, Avalle L, Douglas AT, Mort RL, Byron A, Carragher NO, Pollard
   SM, Brunton VG, Frame MC. An ILK/STAT3 pathway controls glioblastoma stem
   cell plasticity. Dev Cell. 2024 Dec 16;59(24):3197-3212