Dear all, We have an exciting opportunity within the MX group at Diamond Light Source for a highly motivated PDRA to carry out their own innovative research in the development of new methods and their application to structure determination by electron and X-ray diffraction of protein nanocrystals. The post will work within the HeXI/VMXm …
Dear Colleagues, Montana State University (Bozeman Montana) seeks a manager for our cryo-TEM Core Facility (https://www.montana.edu/cryo-electron-microscopy/). The facility currently houses a 200 kV Talos Arctica cryo-TEM equipped with a Gatan K3 direct electron detector, a cryo-capable 120 kV Tecnai Spirit, Vitrobot Mark IV and significant computational resources. The successful candidate will be responsible for daily facility operations, sample …
Applications are invited for a postdoctoral researcher position to study antibody design and molecular mechanisms of modulation of ion channels. You will be part of the Modular Activator and Silencer Therapeutics (MAST) team developing novel platforms of antibodies, E3 ligase-mediated degraders, and proteases, to advance drug discovery, with the opportunity for superb mentorship support from …
Hi everyone, What does it mean if your Rwork and Rfree are exactly the same? I solved a 3.37 Å structure with Phaser-MR and immediately ran 10 cycles of refinement with wxc = 0.1. Everything else at default. The Rwork and Rfree are both 0.1837. Is this bad? Thank you! Justin …
UNIVERSITY OF LIVERPOOL DEPARTMENT OF BIOCHEMISTRY AND SYSTEMS BIOLOGY Cryo-EM STRUCTURAL BIOLOGY POSTDOCTORAL RESEARCH ASSOCIATE Grade 7 (Salary range £38,250 – £40,521 pa) An exciting opportunity has emerged to join the Molecular Biophysics Group to work on a BBSRC-supported collaborative project between the teams from University of Leeds and Liverpool aimed at answering fundamental questions on enzyme mechanism of quinol- dependent integral membrane nitric oxide reductases, a member of respiratory heme- copper oxidase superfamily. The project builds on our recent 2.2Å cryoEM structure of this enzymeand aims to address a number of ambitious questions through well-informed point mutations and high resolution cryoEM structures. In addition to the isolated enzyme, we also aim to obtain the …
We now have an opportunity for an experienced molecular structural biologist, at Post-Doctoral Research Associate level, to further support the structural biology activity on the I04 beamline in the field of chromatin remodelling and histone modification. These projects are pursued as part of the Diamond inhouse research programme and in collaboration with university partners. Suitable …
Dear Colleagues, With the Aquilos 2 cryo-FIB soon available at our Institute (link 1), allow me to advertise a fellowship opportunity in my lab briefly: Overview: This project to be developed at the São Carlos Institute of Physics (IFSC), University of São Paulo (USP) in Brazil, aims to study the in situ structure of mitochondrial …
Dear all, ** We have additional bursary places and have extended the bursary deadline to Monday 4th March ** This is thanks to kind support from: CryoCloud, CryoSol, Dectris, Quantum Detectors, Nanosoft, SubAngstrom and Thermo Fisher Scientific. The bursaries will cover registration fee and two nights accommodation. If you are interested please send a 300 word …
The Sosa Laboratory in the Albert Einstein College of Medicine is currently seeking a highly motivated and talented Postdoctoral Researcher to join our group. Research in our lab is dedicated to uncovering the mechanisms of action of various biological macromolecular machines, employing a diverse set of experimental approaches. The successful candidate will play a key …
Dear All, Applications are invited for a joint postdoctoral scientist position in the laboratories of Dr. Thomas Hund and Dr. Krishna Chinthalapudi in The Davis Heart and Lung Research Institute at the Ohio State University. The research project focuses on understanding the role of ion channels in health and disease. We combine state-of-the-art structural biology …