Dear Colleagues,

Please find below details about a new open position for a
Research Scientist in Protein Sciences at ALPX

Kind regards,

Irina

                                                    Research Scientist in Protein Sciences at
ALPX

Position description:
ALPX is an EMBL spin-off company located in Grenoble,
France. We offer innovative research services based on the
CrystalDirect technology for structural biology and
small-molecule drug discovery to the pharmaceutical and
biotech industries.
We seek a highly experienced and motivated Protein
Production specialist to join the ALPX team.
The successful candidate will be contributing to a range
of exciting structural biology/drug discovery projects,
and will be spearheading the development of our Protein
Engineering and Production platform.
Responsibilities include planning, development,
implementation and optimisation of Standard Operating
Protocols for protein production, from expression to
purification, for quality control, characterization, and
construct optimisation. The position also requires strong
oral and written communication skills as reports are to be
prepared and shared to other ALPX Units (Cryo-EM and
Macromolecular Crystallography) and to clients.

Required knowledge, skills, and abilities:

• Ph.D. in chemistry, biology, physics,
  or a related field, with an excellent track record
• Strong experience in protein
  expression in different organisms (E. coli, insect cells
  and human cells)
• Deep knowledge of protein
  purification, in terms of techniques (affinity,
  chromatography, gel filtration) and instruments (AKTA
  and BioRad systems)
• Extensive practice in protein quality
  control (SDS-PAGE, Western Blot, cross-linking)
• Experience in protein
  characterization by Mass Photometry, Size Exclusion
  Chromatography, Thermal Shift Assay
• Team player with the ability to work
  on several projects in parallel
• Strong oral and written communication
  and organisation skills
• Excellent written and speaking
  English

Preferred knowledge, skills, and abilities:

• Proved experience in AI assisted
  construct design, gene optimization and directed
  mutagenesis
• Demonstrated ability to work on
  challenging targets, such as membrane proteins
• Previous position(s) in
  Industry/CRO/CMO

The position is permanent and immediately available. Deadline
for application: July 10 2025.
If you are enthusiastic about this position but find that
your previous experience does not precisely match every
requirement outlined in the job description, we still
encourage you to apply.
We are looking forward to hearing from you.

Please send your motivation letter, CV, and names of two
referees to recruitment@alpx-services.com