Dear All,

 

Please find details of a PhD position at the University of Leicester below:

 

 

Rethinking receptor recognition in cytokines; their role in asthma and inflammation

The ‘four alpha-helix bundle’ cytokines (IL4/IL13 and IL6/IL11) have a broad range of functions and are crucial for fighting infection and the immune response. These cytokines are validated therapeutic
targets as their dysregulation results in a broad spectrum of pathological conditions including inflammation (asthma, arthritis), sepsis and cancer.

Our previous studies of IL13 and IL6 (DOI: 10.3389/fimmu.2023.1216967) have indicated that they, and related cytokines, exist in at least two states – receptor competent and incompetent. This equilibrium
state provides a new insight into the differing receptor signalling complex formation. We will use a combination of NMR spectroscopy, computational methods and functional assays to interrogate these conformations, enhancing our understanding of receptor recognition
and protein-protein interactions in general. With this knowledge, the potential for the development of small molecule allosteric inhibitors that can trap the cytokine in an ‘incompetent’ state could be realised.

 

Who Should Apply?

We are looking for a highly motivated candidate with a background in biochemistry, structural biology, or immunology. Experience in protein expression, structural techniques, or computational modelling
is desirable but not essential.

 

Funding

The studentship will provide:

• 3.5 year UK tuition fee waiver
• 3.5 year stipend at UKRI rates (for 2024/5 this will be £19,237 pa)

International students will be required to pay the difference between UK and overseas fees. For 2025/6 entry this will be £18,864 per year of study.

It may be possible to provide a full overseas fee waiver to an exceptional overseas candidate but this is not guaranteed.

 

Applicants who hold EU Settled or Pre-Settled status may be eligible for UK fees. Please email apply@le.ac.uk with
a share code so that we can verify your status.

Applicants with any other immigration status in the UK that may permit home fees please email the details to apply@le.ac.uk so
we can verify your status. 

 

Department: Molecular and Cell Biology

Application deadline: 30 March 2025

Start date: 22 September 2025