Industrial PhD student position available in Lund, Sweden
We are looking for outstanding graduates from all over the world and are delighted to provide them with the best possible conditions for their
scientific careers. The graduate program Lund University at faculty of medicine
provides an interdisciplinary education for doctoral candidates at the interface of molecular life sciences and
clinical science.
In addition, the candidate will be employed and strongly connected to the scientific activities at a small biotech company Apoglyx
AB. If you have a passion for
structural biology,
molecular biology,
cell biology, protein biochemistry
and drug discovery and want to work
in an interdisciplinary setting at
Lund University at faculty of medicine–
this is the doctoral program for you!
You have:
·
an above-average master’s or comparable degree in molecular biology, biochemistry, or any related areas, awarded
by March
2025 or earlier;
·
some experience with
protein biochemistry and/or
structural biology;
·
very good written and spoken English;
We offer:
·
cutting-edge research
within medical structural biology with unique conditions as you will be employed by the biotech company Apoglyx AB (website: https://apoglyx.com) and admitted to the doctoral program at faculty of medicine at Lund University
·
4
years funding to work on your doctoral project
·
a degree from
Lund University
·
excellent structured supervision
·
a diverse community to exchange ideas with
·
a flexible and challenging curriculum of
scientific courses and transferable skills
·
support for attending conferences to present your work
·
an international graduate program in one of Europe’s most exciting cities
Timeline:
·
Apply by the 1st of
January 2025
by sending an email to Prof. Lindkvist
·
Short-listed candidates are invited to
Lund
for interviews in January 2025
·
Successful candidates start their doctorate
as soon as possible, at the lastest the 1st of June 2025
Application:
Please prepare your CV and motivation letter, your academic record and the name of two referees
willing to provide references, then apply by the 1st
of January 2025.
Contact:
Prof. Karin Lindkvist (karin.lindkvist@med.lu.se)
Short summary of the project with a few references from Lindkvist laboratory
related to the project.
Maintaining a balance between activation and suppression of immune response is
critical for the immune system.
Systemic Inflammatory Response Syndrome (SIRS) is an exaggerated response of the immune system and is a
potentially life-threatening medical condition that is characterized by a self-harming immune response. SIRS can
be initiated by an infection (then called sepsis), or by sterile causes of cell damage, such as trauma. A hallmark
of
both sepsis and SIRS is the massive recruitment neutrophils from the bone marrow into the circulation. Together
with academic collaborators, ApoGlyx AB has demonstrated that genetic ablation of AQP9 is an
effective way for
interfering with SIRS, by preventing tissue infiltration of neutrophils. Based on these promising results,
the aim is to
decipher the structural-functional activity of AQP9 and develop a series of compounds blocking its activity. The 3D structure of AQP9 will be determined with and without inhibitors
by
single particle cryo-EM to augment structure-based drug design. Furthermore, the
inhibitor-effect of the newly developed compounds will be evaluated in neutrophils.
Molecular
basis for human aquaporin inhibition.
Huang P, Åbacka H, Wilson CJ, Wind ML, Rützler M, Hagström-Andersson A,
Gourdon P, de Groot BL, Venskutonytė R, Lindkvist-Petersson K.
Proc Natl Acad Sci U S A.
2024 Feb 13;121(7):e2319682121. doi: 10.1073/pnas.2319682121.
SMS121, a new inhibitor of CD36, impairs fatty acid uptake and viability
of acute myeloid leukemia
Åbacka H, Masoni S, Poli G, Huang P, Gusso F, Granchi C, Minutolo F, Tuccinardi
T, Hagström-Andersson AK, Lindkvist-Petersson K.
Sci Rep.
2024 Apr 20;14(1):9104. doi: 10.1038/s41598-024-58689-1.
Cryo-EM structure supports a role of AQP7 as a
junction protein.
Huang P, Venskutonytė R Prasad
RB, Ardalani H, de Maré SW, Fan
X, Li P, Spégel P, Yan N, Gourdon
P, Artner I, Lindkvist-Petersson K.
Nature Commun.
2023 Feb 3;14(1):600. doi: 10.1038/s41467-023-36272-y
*******************************************************
Professor Karin Lindkvist
Experimental Medical Science
Medical Structural Biology
Lund University
BMC C13
221 84 Lund, Sweden
Tel: +46 2228041
Tel (mobile): +46 734222786
Email:
Karin.Lindkvist@med.lu.se
LINXS – Lund Institute of advanced Neutron and X-ray Science
Scheelevägen 19
SE-223 70 Lund
Sweden
Home page:
http://www.linxs.se/
Lund university internal post: Hämtställe 37
