Dear all,
2 PhD positions
are available immediately in
the research group of Eva Wolf in Mainz (Germany). Research in the Wolf group is focused on the structural, biochemical and biophysical analyses of proteins involved in the circadian (day-time dependent) and circalunar (monthly) regulation of cellular, physiological
and behavioral processes. We recently described molecular mechanisms and Cryo-EM structures of a marine cryptochrome (L-Cry), which is involved in the synchronization of moon-controlled maturation rhythms of marine worms with the lunar cycle (Pöhn,
Krishnan et
al,
Nat
Comm
2022; Vu, Behrmann et
al,
Nature
Comm 2023;
Zurl et
al,
PNAS
2022). The prospective PhD students
will further characterize LCry’s reponses to sunlight and moonlight and its molecular interactions with downstream ligands. In a highly interdisciplinary approach, they will
apply a wide range of techniques
including UV/VIS spectroscopy, biochemical and biophysical protein interaction studies, protein expression and purification, X-ray crystallography, Cryo-EM, pulldown/MS, molecular biology and functional cell-based assays.
Candidates
with a strong interest in structural biology, protein biochemistry, biophysics and structure-function relationship and a significant previous exposure to these research areas during their master education are encouraged to apply.
Please send your
application including your CV, motivation letter, certificates and contact details for two referees in one pdf file to Eva Wolf (evawolf1@uni-mainz.de).
We encourage PhD
candidates to also apply to the International PhD Program (IPP) of the Mainz Institute of Molecular Biology (IMB) before April 17th.
Information about the IPP can be found under https://www.imb.de/students-postdocs/international-phd-programme/apply-to-ipp
.
————————————————————-
Prof. Dr. Eva Wolf
Structural Chronobiology
University and IMB Mainz
Hanns-Dieter-Hüsch-Weg 17
55128 Mainz, Germany
https://chrono-wolf.biologie.uni-mainz.de/