Dear All,

We are recruiting
a highly motivated a highly motivated Post-Doctoral Scientist to join our team at EMBL Grenoble,
interested in the molecular mechanisms underlying the
architecture and assembly
of muscle sarcomeres, particular Z-discs. We use a
multidisciplinary approach to
tackle complex biological problems by combining complementary structural biology techniques,
computational
modelling, and other biochemical and biophysical methods. The
main focus of
this position will be integrative structural
studies of reconstituted assemblies.

Your role

•          Taking
up and leading a challenging structural biology project

•          Designing
and performing experimental procedures

•          Analysing
and interpreting experimental data

•          Taking
part in regular group meetings, unit seminars and international
conferences

•          Staying
up to date with the literature and the latest methodological
developments
relevant to the project

You will embark on an
exciting journey
to decipher the structures of selected reconstituted complexes
and
macromolecular condensates using an integrative structural
biology approach,
which encompasses molecular biophysics characterisation,
combined with small
angles X-ray scattering, macromolecular crystallography, and
cryo-electron
microscopy/tomography, depending on their size and dynamics. As
a team member,
you will play a crucial role in uncovering the detailed
biophysical and
structural principles that regulate complex assembly. Joining
collaborative
efforts, you will contribute to the generation of a 4D
multiscale integrative
molecular model.

You have

• PhD degree in molecular biology or a related
  field

·       Extensive
experience in molecular cloning, expression, and purification of
protein
complexes is essential.

·       Prior
knowledge of crystallography and/or single-particle electron
microscopy is
needed.

·       Track
record of writing papers as evidenced by publications or
submitted manuscripts.

• Independence and ability to solve problems
• Good time management and pro-active attitude
• Excellent communication skills and ability to
  work in a team

You might also have

·      
Previous experience in
complementary structural biology methods (e.g. SAXS), molecular
and cell
biophysics approaches and cell culture will be considered an
advantage.

·      
Experience with
cryo-electron tomography.

·      
Experience with
working in multidisciplinary research teams.

Why join us

The European Molecular
Biology
Laboratory (EMBL) is one of the highest-ranked scientific
research
organisations in the world aimed
to
explore the secrets of life. The Headquarters Laboratory is
located in
Heidelberg (Germany) and further Units are situated in Grenoble
(France),
Hamburg (Germany), Hinxton (UK), Rome (Italy) and Barcelona
(Spain).

EMBL Grenoble shares
the European
Photon and Neutron Science (EPN) Campus with the European
Synchrotron Radiation
Facility (ESRF), the Institut Laue Langevin (ILL) and
the French
national Institut de Biologie Structurale (IBS), whose
complementary and
integrated facilities provide a vibrant environment for
structural biologists.

EMBL Grenoble enables
access to
state-of-the-art structural biology technologies with the local
EM facility
equipped with the T12 screening microscope and a 200kV Glacios
microscope with
Falcon4i/SelectrisX detector. Additionally, we have a regular
access to five
300kV microscopes located locally at ESRF and at EMBL
Heidelberg. Other
facilities include high-performance computing cluster, dedicated
GPU
workstations for data processing and deep learning applications,
ESRF
synchrotron X-ray beamlines, high-field NMR at the IBS as well
as mammalian and
insect cell facilities, biophysical platform, confocal
microscopy and
high-throughput crystallization facilities.

EMBL is an inclusive,
equal opportunity
employer offering attractive conditions and benefits appropriate
to an
international research organisation with a very collegial and
family friendly
working environment. The remuneration package comprises a
competitive salary, a
comprehensive pension scheme, medical, educational and other
social benefits,
as well as financial support for relocation and installation,
including your
family.

What else you need to know

We are Europe’s
flagship research
laboratory for the life sciences – an intergovernmental
organisation performing
scientific research in disciplines including molecular biology,
physics,
chemistry and computer science. We are an international,
innovative and
interdisciplinary laboratory with more than 1900
employees from many nations, operating across six sites, in
Heidelberg (HQ),
Barcelona, Hinxton near Cambridge, Hamburg, Grenoble and Rome.

Our mission is to
offer vital services
in training scientists, students and visitors at all levels; to
develop new
instruments and methods in the life sciences and actively engage
in technology
transfer activities, and to integrate European life science
research.

The contract
is for 3 years.

Please
compile an application package containing:

•          Letter
of interest

•          Your
CV

•          Contact
details for three references

Please apply online
at: https://www.embl.org/jobs/position/GR00217

Deadline: 19.11.2023

Shortlisting Deadline: 2 weeks after deadline

Interviews: 2-3 weeks
after deadline

Prospective start date: ASAP

Contract Duration: 3 years

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