Dear all,

 

Our Structural Biology group within SANOFI (Cambridge
Massachusetts) has an opening for a Senior Scientist (Job ID: R2695834) and we
are seeking a highly motivated scientist with a solid background in structural
biology and strong hands-on experience in CryoEM.

 

If you are interested in applying for this position, please
follow the link provided below.

 

Thanks in advance for your interest!

Best

Eduardo Bruch

 

https://sanofi.wd3.myworkdayjobs.com/SanofiCareers/job/Cambridge-MA/Senior-Scientist_R2695834

 

Senior. Scientist – U.S. IDD
structural biology

We are looking for a highly
motivated scientist to join our structural biology group at Sanofi in Cambridge
MA.  As a key member of our dynamic team, you will be responsible for
determining critical structural biology data through both cryo-electron
microscopy and x-ray crystallography; actively pursuing solutions for unmet
medical needs in diverse therapeutic areas and collaborating with
multidisciplinary teams within Sanofi in Cambridge, US, Frankfurt, Germany and
Paris, France. The successful candidate will excel in a fast-paced, highly
diverse discovery environment, will have a strong focus on scientific rigor,
have proven success in organized and independent work, and an exceptional
attention to detail. Applicants who are passionate about structural biology are
encouraged to apply.

Candidate profile:

·      
CryoEM expert scientist that can independently design and carry
out EM experiments and interpret results (sample preparation, data collection,
data processing and solving structures). Analyze interactions and propose
structure-based improvements for small-molecule drug discovery. Enable building
state-of-the art technologies in related areas to enhance research activities.

·      
Work closely with Sanofi digital to automate CryoEM data
collection processes to evaluate samples in medium-throughput manner. Python or
other programming languages for building pipelines for data collection and
processing is a plus.

·      
Share responsibility for maintaining the Glacios cryo-electron
microscope (beam alignment, calibration, cryo-cycling, etc.).

·      
Expertise with all related softwares (CryoSparc, SerialEM,
Relion, cisTEM, Chimera, Eman2, Coot, phenix, ccp4 suite etc.).

·      
Provide expertise to project teams pursuing different drug
modalities at Sanofi.

·      
Manage and deliver on projects in a timely fashion.

·      
Train new users on finer aspects of CryoEM grid preparation and
data collection when necessary.

·      
Experience in X-ray crystallography is a strong plus. The
candidate will be expected to train to support this area in case of no prior
experience.

·      
Experience in expression and purification strategies using
bacterial, insect, and mammalian hosts and membrane protein purification. The
candidate should be capable of purifying protein for the structural biology
group when needed.

·      
Experience in biophysical characterization (SPR, DSF, MST etc.)
is a plus.

·      
Have excellent communication skills. Should be able to clearly
articulate data, project strategies both internally and externally.

Qualifications:

·      
PhD with 3+yrs of postdoctoral and/or industry experience in
Structural Biology, Biophysics, Protein Biochemistry or related discipline.

·      
Strong experience in cryo-EM is required.

·      
The ideal candidate should be detail-oriented, organized and
demonstrate good lab practices.

·      
Must be a collaborative team player with strong communication
skills.

Sanofi Inc. and its U.S.
affiliates are Equal Opportunity and Affirmative Action employers committed to
a culturally diverse workforce. All qualified applicants will receive consideration
for employment without regard to race; color; creed; religion; national origin;
age; ancestry; nationality; marital, domestic partnership or civil union
status; sex, gender, gender identity or expression; affectional or sexual
orientation; disability; veteran or military status or liability for military
status; domestic violence victim status; atypical cellular or blood trait;
genetic information (including the refusal to submit to genetic testing) or any
other characteristic protected by law.

As a healthcare company and
a vaccine manufacturer, Sanofi has an important responsibility to protect
individual and public health. All US based roles require individuals to be
fully vaccinated against COVID-19 as part of your job responsibilities.

According to the CDC, an
individual is considered to be “fully vaccinated” fourteen (14) days after
receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the
single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees,
is to be fully vaccinated 14 DAYS PRIOR TO START DATE.

#GD-SA 
#LI-SA

At Sanofi
diversity and inclusion is foundational to how we operate and embedded in our
Core Values. We recognize to truly tap into the richness diversity brings we
must lead with inclusion and have a workplace where those differences can
thrive and be leveraged to empower the lives of our colleagues, patients and
customers. We respect and celebrate the diversity of our people, their
backgrounds and experiences and provide equal opportunity for all.