Building on
our recent work (1-6), the project aims to develop
direct anticoagulants against alternative targets in the
blood coagulation cascade that have not been clinically
exploited to date or represent a completely unexplored
mechanism of intervention.

Informal
inquiries can be addressed to Jorge Ripoll-Rozada (jorge.rozada@ibmc.up.pt) or Pedro
J.B. Pereira (ppereira@ibmc.up.pt).

Please note
that applications will be considered ONLY if
submitted (together with ALL accompanying documentation)
before
2023/03/31, using the online tool at https://dozer.i3s.up.pt/applicationmanagement/#/addapplications/ResearcherFTC_Proj2020i3S06032023.

Further information:
https://dozer.i3s.up.pt/fileupload/downloadfile/viewpdfnewtab/72182470deba408df576958ce5c5befa
(in Portuguese)
or
https://dozer.i3s.up.pt/fileupload/downloadfile/viewpdfnewtab/5efe13569f63a911df16b39ab7bd8f3a
(in English).

 

1 – Thompson, R.E.; Liu,
X.; Ripoll-Rozada, J.; Alonso-García, N.; Parker, B.L.;
Pereira, P.J.B.; Payne, R.J. (2017) Tyrosine sulfation
modulates activity of tick-derived thrombin inhibitors.
Nature Chemistry
9, 909-917.
DOI: 10.1038/nchem.2744

2
– Watson, E.; Liu, X.; Thompson, R.; Ripoll-Rozada, J.;
Wu, M.; Alwis, I.; Gori, A.; Loh, C.-T.; Parker, B.;
Otting, G.; Jackson, S.; Pereira, P.J.B.; Payne, R.
(2018) Mosquito-derived anophelin sulfoproteins are
potent anti-thrombotics. ACS Central Science
4, 468-476.
DOI: 10.1021/acscentsci.7b00612

3
– Watson, E.E.; Ripoll-Rozada, J.; Lee, A.C.; Wu.
M.C.L.; Franck, C.; Pasch, T.; Premdjee, B.; Sayers, J.;
Pinto, M.F.; Martins, P.M.; Jackson, S.P.; Pereira,
P.J.B.; Payne, R.J. (2019) Rapid Assembly and Profiling
of an Anticoagulant Sulfoprotein Library. Proceedings of the
National Academy of Sciences of the USA 116,
13873-13878. DOI: 10.1073/pnas.1905177116

4
– Calisto, B.M.; Ripoll-Rozada, J.; Dowman, L.J.;
Franck, C.; Agten, S.M.; Parker, B.L.; Veloso, R.C.;
Vale, N.; Gomes, P.; de Sanctis, D.; Payne, R.J.;
Pereira, P.J.B. (2021) Sulfotyrosine-Mediated
Recognition of Human Thrombin by a Tsetse Fly
Anticoagulant Mimics Physiological Substrates. Cell Chemical
Biology 28,
26-33. DOI: 10.1016/j.chembiol.2020.10.002

5
– Agten, S.M.; Watson, E.E.; Ripoll-Rozada, J.; Dowman,
L.J.; Wu, M.; Alwis, I.; Jackson, S.; Pereira, P.J.B.;
Payne, R.J. (2021) Potent trivalent inhibitors of
thrombin through hybridization of salivary sulfopeptides
from hematophagous arthropods. Angewandte Chemie
International Edition 60, 5348-5356. DOI:
10.1002/anie.202015127

6
– Dowman, L.J.; Agten, S.M.; Ripoll-Rozada, J.; Calisto,
B.M.; Pereira, P.J.B.; Payne, R.J. (2021) Synthesis and
evaluation of peptidic thrombin inhibitors bearing
acid-stable sulfotyrosine analogues. Chemical
Communications 57, 10923-10926. DOI:
10.1039/d1cc04742f