Dear colleagues,

 

I would like to advertise an EPSRC-funded studentship that is available in my lab at the University of Edinburgh:

 

“The physics and structural biology of supramolecular protein self-assembly in meiotic chromosome synapsis”

 

One of the largest protein structures in the cell is the synaptonemal complex (SC), which synapses together homologous chromosomes to facilitate their recombination during meiosis. This project aims to uncover the physics of how the SC
is formed through self-assembly of its protein components. This will involve a wide range of biochemical, biophysical, structural biology, computational and theoretical modelling methods. The laboratory-based methods include recombinant protein expression
and purification, light and X-ray scattering, X-ray crystallography, cryo-EM and cryo-ET, which will include data collection at the Diamond Light Source synchrotron facility (www.diamond.ac.uk).
Computational and theoretical methods include AI-based structural modelling, molecular dynamics, and building and simulating mathematical models of bio-assemblies, which will be performed in collaboration with the Institute for Condensed Matter and Complex
Systems (https://www.ph.ed.ac.uk/icmcs).

 

This PhD provides an excellent opportunity for a student with a biochemical/structural biology, computational or physics background to engage in cutting-edge research into the physics of life.

 

For more information, please see:

 

https://www.findaphd.com/phds/project/the-physics-and-structural-biology-of-supramolecular-protein-self-assembly-in-meiotic-chromosome-synapsis/?p156057

 

To apply, please follow the ‘institution website’ link at the above address and complete the application form.

 

Application deadline: 31^st March

 

Best wishes,

 

Owen.

 

Dr Owen Davies

Wellcome Senior Research Fellow

Institute of Cell Biology

University of Edinburgh

Michael Swann Building

Max Born Crescent

Edinburgh EH9 3BF

United Kingdom