We are
looking for a highly motivated post-doc to join the
Macromolecular Structure group of i3S – Instituto de
Investigação e Inovação em Saúde
(https://www.i3s.up.pt/research-group.php?groupid=113) in
Porto, Portugal. The position, funded for up to 13 months,
is expected to start in May 2023.

Building on
our recent work (1-6), the project aims to develop direct
anticoagulants against alternative targets in the blood
coagulation cascade that have not been clinically
exploited to date or represent a completely unexplored
mechanism of intervention.

Informal
inquiries can be addressed to Jorge Ripoll-Rozada (jorge.rozada@ibmc.up.pt) or Pedro
J.B. Pereira (ppereira@ibmc.up.pt).

Please note
that applications will be considered ONLY if
submitted (together with ALL accompanying documentation) before
2023/03/31, using the online tool at https://dozer.i3s.up.pt/applicationmanagement/#/addapplications/ResearcherFTC_Proj2020i3S06032023.

Further information:
https://dozer.i3s.up.pt/fileupload/downloadfile/viewpdfnewtab/72182470deba408df576958ce5c5befa
(in Portuguese)
or
https://dozer.i3s.up.pt/fileupload/downloadfile/viewpdfnewtab/5efe13569f63a911df16b39ab7bd8f3a
(in English).

 

1
– Thompson, R.E.; Liu, X.; Ripoll-Rozada, J.;
Alonso-García, N.; Parker, B.L.; Pereira, P.J.B.; Payne,
R.J. (2017) Tyrosine sulfation modulates activity of
tick-derived thrombin inhibitors. Nature Chemistry
9, 909-917.
DOI: 10.1038/nchem.2744

2 –
Watson, E.; Liu, X.; Thompson, R.; Ripoll-Rozada, J.; Wu,
M.; Alwis, I.; Gori, A.; Loh, C.-T.; Parker, B.; Otting,
G.; Jackson, S.; Pereira, P.J.B.; Payne, R. (2018)
Mosquito-derived anophelin sulfoproteins are potent
anti-thrombotics. ACS
Central Science 4, 468-476. DOI: 10.1021/acscentsci.7b00612

3 –
Watson, E.E.; Ripoll-Rozada, J.; Lee, A.C.; Wu. M.C.L.;
Franck, C.; Pasch, T.; Premdjee, B.; Sayers, J.; Pinto,
M.F.; Martins, P.M.; Jackson, S.P.; Pereira, P.J.B.;
Payne, R.J. (2019) Rapid Assembly and Profiling of an
Anticoagulant Sulfoprotein Library. Proceedings of the
National Academy of Sciences of the USA 116,
13873-13878. DOI: 10.1073/pnas.1905177116

4 –
Calisto, B.M.; Ripoll-Rozada, J.; Dowman, L.J.; Franck,
C.; Agten, S.M.; Parker, B.L.; Veloso, R.C.; Vale, N.;
Gomes, P.; de Sanctis, D.; Payne, R.J.; Pereira, P.J.B.
(2021) Sulfotyrosine-Mediated Recognition of Human
Thrombin by a Tsetse Fly Anticoagulant Mimics
Physiological Substrates. Cell Chemical Biology
28, 26-33. DOI:
10.1016/j.chembiol.2020.10.002

5 –
Agten, S.M.; Watson, E.E.; Ripoll-Rozada, J.; Dowman,
L.J.; Wu, M.; Alwis, I.; Jackson, S.; Pereira, P.J.B.;
Payne, R.J. (2021) Potent trivalent inhibitors of thrombin
through hybridization of salivary sulfopeptides from
hematophagous arthropods. Angewandte Chemie
International Edition 60, 5348-5356. DOI:
10.1002/anie.202015127

6 –
Dowman, L.J.; Agten, S.M.; Ripoll-Rozada, J.; Calisto,
B.M.; Pereira, P.J.B.; Payne, R.J. (2021) Synthesis and evaluation
of peptidic thrombin inhibitors bearing acid-stable
sulfotyrosine analogues. Chemical
Communications 57, 10923-10926. DOI:
10.1039/d1cc04742f