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Open Positions:

Multiple Ph.D. and
postdoctoral positions
are available in the framework
of the SNF Sinergia project “Linking time-resolved structures and signal
transduction within multi-domain photosensors”. The project involves
research groups at the Paul Scherrer Institute and the University of Zurich in
Switzerland and the Hebrew University of Jerusalem in Israel. With focus on (1)
structural, (2) spectroscopic and (3) computational methods each
group targets a different aspect within our interdisciplinary study of photosensors
dynamics.

Project description:

Our team employs the exciting
new possibilities in
time-resolved structural biology offered by the Swiss Light Source (SLS) and the
Swiss X-ray free-electron laser
(SwissFEL) to investigate the allosteric signaling between domains in various
photoactive protein complexes. Time-resolved IR spectroscopy will allow to
specify selected time points, at which the
population of intermediates is maximized and their 3D structures can be determined. Quantum chemical and molecular dynamics simulations based on
these 3D structures will allow
to cross-validate the experimental IR spectra.
Final cell biology experiments
will close the loop from the initial stimulation to signaling output.

Basic requirements:

Eligible
candidates for a postdoctoral position should have a Ph.D. degree and a proven track record in chemical
physics, biology, biophysics, or related fields. Applicants for a Ph.D.
position should have a master
degree and marked enthusiasm for interdisciplinary research. Adequate
communication skills in English are
mandatory.

Specific knowledge, experience and skills:

(1) Structural Biochemistry: Dr. Jörg Standfuss at
the Paul Scherrer Institute is searching for experts in membrane protein expression,
purification, and X-ray crystallography for conducting time-resolved pump-probe
experiments at SLS and SwissFEL. Supplementary reading: Skopintsev, et al.
Femtosecond-to-millisecond structural changes in a light-driven sodium pump. Nature
583, 314–318 (2020).

Applications via https://www.psi.ch/en/pa/job-opportunities/55406-postdoctoral-fellow

(2) Infrared Spectroscopy: Prof. Peter Hamm at the University
Zurich is seeking candidates preferentially with knowledge in time-resolved
(femtosecond) laser spectroscopy, ideally combined with expertise in protein
expression and purification. Supplementary reading: Bozovic, et al. Using Azobenzene Photocontrol to Set Proteins in Motion, Nature
Rev. Chem. 6, 112–124 (2022).

Applications via email to peter.hamm@chem.uzh.ch

(3) Computational Chemistry: A project in the group of Prof.
Igor Schapiro at the Hebrew University of Jerusalem will focus on simulating
photoreceptor proteins using quantum
chemical methods, molecular dynamics and multiscale modelling. Supplementary reading:  Church et al., Deciphering the
Spectral Tuning Mechanism in Proteorhodopsin: The Dominant Role of
Electrostatics Instead of Chromophore Geometry, Chem. Eur. J. 28, e202200139.

Applications
via email to igor.schapiro@mail.huji.ac.il

Back to the vacancy list