Postdoctoral Position: Structural biology of the actin cytoskeleton

Postdoctoral
Position: Structural biology
of the actin cytoskeleton

Djinovic group is interested in the molecular mechanisms underlying the
architecture and
assembly of the actin based
cytoskeleton. This project
focuses on ubiquitous human proteins
α-actinin-1 and -4, which self-associate to form a homo- and
hetero dimeric units
that cross-link actin filaments in calcium-regulated manner. The
project is
jointly funded by Austrian and Slovene Science Funds and is a
close
collaboration between Djinovic group at Vienna, Austria, and
Pavsic group at University
of Ljubljana, Slovenia. The two young and dynamic groups will
join forces to understand the
detailed molecular mechanism of regulation
of this essential F-actin crosslinking
protein by calcium and specific phosphoprylation events.

We employ
an
integrated approach by combining
biochemistry, cell, chemical
and structural
biology approaches, including X-ray crystallography, small angle
scattering and
(starting) cryo-EM. The successful candidates will be involved
in all aspects
of the project, including protein expression, purification,
biophysical, biochemical
characterization and integrative structural biology.

Qualifications
and experience: The
applicants should hold a PhD degree in a
relevant field and two years of post-doctoral experience in a
structural
biology lab. Strong background in molecular cloning, expression,
and purification
of protein complexes is essential. Prior knowledge of
crystallography and/or
single-particle electron microscopy is needed. Excellent spoken
and written
English are required.

The
successful applicants will work in a stimulating scientific
environment: Department
for Structural and
Computational Biology
at Max Perutz
Labs, a
joint venture between University of Vienna and Medical
University of Vienna.
The Labs are located at Vienna
BioCenter,
the largest molecular life science hub in Austria. We are
equipped equipped with state-of-the-art research
infrastructure for experimental and computational work, and have
access to facilities at Vienna
Biocenter Core Facilities,
which includes mass-spectrometry, a blend of Protein
technologies and electron
microscopy instruments (Glacios, Krios). The group has in
addition access to cryo-EM
Titan-Krios through BAG at ESRF and to major European
synchrotron high-brilliance
X-ray sources.

1. A concise
description of research experience, including a
list of published peer-reviewed articles.

2. Copy of the PhD diploma (or equivalent).

3. Contact details for three references, of which
one should be your
PhD supervisor.

Please prepare the
application as a single package
in PDF format, and
send it to <admin.vbc5@univie.ac.at>,
subject Postdoctoral position in Djinovic Lab.

Further
information can be obtained from Kristina Djinovic Carugo kristina.djinovic@univie.ac.at.

Closing
date:
review of applications begins immediately and will continue
until the position
is filled.

WEB-PAGES

https://www.maxperutzlabs.ac.at/research/research-groups/djinovic

https://www.maxperutzlabs.ac.at/

https://structbio.univie.ac.at/

https://structbio.univie.ac.at/research-infrastructure-facilities/

https://www.viennabiocenter.org/

https://www.viennabiocenter.org/facilities/

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-- 
------------------------
Kristina Djinovic Carugo
Head of EMBL Grenoble

Email:	kristina.djinovic@embl.org			
Website: http://www.embl.fr			
Tel:	+33 4 76 20 7876   Secretary +33 4 76 20 7123	
Mobile: +33 6 60 72 71 61							
EMBL Grenoble, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble Cedex 9, France
---

Back to the vacancy list

From: Kristina Djinovic Carugo

Date: Thu, 17 Nov 2022