If you are an
enthusiastic, committed and responsible student with a love for science and if
you are looking for an opportunity to develop novel therapeutic proteins to
battle cancer, then our team is looking for you. The Shifman lab in the Hebrew
University of Jerusalem is an international and interdisciplinary group located
at the in the Givat Ram campus of the Hebrew University as part of the Biological
Chemistry Department. (https://openscholar.huji.ac.il/shifmanlab/).
We offer a 3-year fully funded postdoctoral position in our lab.  

Project description

The goal of this project
is to engineer high-affinity specific binders to a known oncogene Ras, whose mutations
are found in 30% of all human cancers. Such proteins will be constructed
starting from a natural human protein that is able not only to inhibit Ras
pro-cancer activities and but also exhibits anticancer activity of its own. Furthermore,
the protein will be engineered with capabilities to penetrate tumor environment
and to enter cancer cells, where mutated Ras is located. All our projects are
interdisciplinary and utilize a combination of structural modeling, experimental
directed evolution, biophysical and structural methods for protein characterization,
and cellular biology.

 Requirements

Ph. D.
in Biochemistry, Biophysics, Biotechnology or Biology. Experience in molecular
biology, protein expression/purification and cellular biology. Computational
biology experience is a plus.

Contact Julia Shifman: jshifman@mail.huji.ac.il