Post-doctoral positions for the study of signaling complexes using X-ray crystallography, Cryo-EM and NMR.

The Page Laboratory at the University of Connecticut Health Center has an immediate opening for up to
two post-doctoral candidates to study eukaryotic signaling enzymes, with a focus on the function of phosphatases that form large signaling complexes and PPP drug/inhibitor development (SHP2, PPPs, PhosTacs). All studies combine X-ray crystallography
and/or cryo-EM/NMR with biochemical and in situ experiments, allowing post-docs to augment their training in those techniques that are new. Applicants with a strong backgrounds in biochemical techniques, and especially eukaryotic protein expression and protein crystallization,
are encouraged to apply.

The Page laboratory is housed in a newly renovated ~250,000 sq. ft. research laboratory in Farmington, CT. The laboratories are open-lab-space facilities and allow close interaction with the adjunct structural biology and molecular/cell
biology groups at UConn Health. The Page laboratory is equipped with all necessary infrastructure to produce (E. coli, Sf9, mammalian), purify and analyze protein and protein complexes (ITC, SPR etc.) and crystallization robotics for crystal production (Art
Robbins Gryphon LCP nano-liter crystallization robot; Art Robbins CrysCam).

Outstanding UCHC facilities include a Bruker Venture D8 system (IμS Diamond source) with a Photon III M14 detector and cold stream is available for crystal screening and data collection for in-house data collection, synchrotron
access at NSLS-II, SSRL, Diamond and high-field NMRs (Bruker Avance Neo 600 MHz and 800 MHz NMR spectrometers (installed in 2021). Both spectrometers are equipped with four independent channels for 1H, 13C, 15N and 2H observation and decoupling and TCI-HCN
cryo-probes (1H, 13C, 15N cooled).

UCHC has a welcoming, collaborative and vibrant environment for structural, biochemical and translational research. Farmington, CT, is located in New England between Boston (90 min.) and New York City (90 min). Starting date,
salary and project details are negotiable.

Please e-mail a Cover Letter and CV to Rebecca Page (rpage@uchc.edu).

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