Job Summary

ModeX Therapeutics is seeking a highly
talented and motivated research scientist with expertise in the field of
antibody engineering to join our team. 
The candidate will be part of an established multidisciplinary team
advancing discovery efforts on our earlier-stage programs as well as moving
novel therapeutic antibodies into clinic. 
The individual will work in the state-of-the-art laboratory and is
responsible for experimental design, execution, data analysis, and record
keeping and presentation.  This is an
exciting opportunity to be part of a cross-functional team and contribute to
the development of cutting-edge biotherapeutics in a fast-paced, rapidly
growing biotech company with a bold vision. 

Company

ModeX Therapeutics, a subsidiary of OPKO Health, is a biotech startup based
in Massachusetts dedicated to the concept of modulating multiple disease
targets with innovative multi-targeting strategies. It was founded by Dr. Elias
Zerhouni and Dr. Gary J. Nabel in 2020 with a team of scientists with proven
track record from early research to clinical development, regulatory approvals,
and commercialization. ModeX is pursuing the development of novel
immune-oncology therapeutics for cancers and biotherapeutics against infectious
disease.

Major responsibilities

·        
Interact closely and be part of
interdisciplinary biologics research teams to drive the discovery of innovative therapeutic antibodies and the
optimization of their biological and biophysical properties.

·        
Contribute to ModeX’s multi-targeting
strategy through antibody discovery campaigns and structure-based antibody
design.

·        
Develop and
implement high-throughput antibody expression and purification platforms. Enhance
optimization of workflows

·        
Immunogen immunization
strategy design. Single B cell sorting and/or screening technologies.

·        
Interpret results and present/communicate
with cross-functional colleagues for successful execution and completion of
projects.

·        
Stay
scientifically current and contribute to the implementation of new technology
and instrumentation.

·        
Ensure effective,
high-quality, timely and appropriate documentation in electronic laboratory
notebooks.

Qualifications

·        
PhD in biochemistry, structure
biology or other life science disciplines with 3+ years of relevant experience antibody
engineering.

·        
Hands-on experience in
antibody generation and optimization (affinity modulation, humanization, PTM
mitigation, etc.) in an industrial setting with strong track record of delivery
of high quality antibodies.

·        
Expertise in immunology,
B cell biology, cloning, next gen. sequencing and data analysis. Hands on experience
in hybridoma/B cell cloning, automation, Elisa, BLI/SPR, and FACS.

·        
Knowledge in protein
engineering using direct evolution methods such as yeast surface and mammalian
display.

·        
Knowledge in antibody
structure and experience in structure-based protein engineering is preferred.

·        
Computer skills,
including large dataset analysis and basic scripting

·        
Excellent written and
oral communication, organization, and data analysis skills.  Outstanding troubleshooting and problem-solving
skills.

·        
Highly adaptable to a
fast-paced work environment and capable to work both independently and
collaboratively within project teams.

To apply, please send cover letter and CV
to Ronnie.Wei@ModeXTX.com and careers@ModeXTX.com