Dear colleagues
Expression and Purification Scientist, Biochemist, Structural Biologist
group Structural Biology of Novel Drug Targets in Human Diseases (https://noveltargets-palencia.com), at the Institute for Advanced Biosciences
(Grenoble) to work on the expression, purification of protein-RNA complexes for
structural studies, and their interactions with inhibitors in the field of
infectious diseases and cancer.
In addition to structural biology
and biophysical techniques, our laboratory also uses a wide range of approaches,
from biochemistry and genetics to in vivo animal studies (in
collaboration). We seek an outstanding candidate with training in molecular biology,
protein/RNA biochemistry, with a strong interest in structural biology –crystallography
or cryo-electron microscopy (EM)– to support
the study of novel protein drug targets.
The successful candidate will use
the in-house IAB facilities for protein production in different systems; other
structural biology facilities of the Partnership for Structural Biology in
Grenoble (EMBL-ESRF-IBS-ILL, http://www.psb-grenoble.eu); and will interact with industrial partners.
Applicants should possess experience
in molecular biology and protein production by
using mammalian cells, bacteria or insect cells. Experience in the assembly and purification of protein-RNA
complexes, crystallization and/or preparation of samples for EM studies would
be an advantage. Motivation to work in a multidisciplinary and international
environment is fundamental.
The candidate will work in the
heart of the French Alpes (Grenoble) at the Institute for Advanced Biosciences
(IAB), where creativity and excellence are fundamental to advance biomedical
research and science education. The IAB is a research center of the University
of Grenoble-Alpes, the French National Institute of Health and Medical Research
(INSERM), and the French National Center for Scientific Research (CNRS).
Grenoble provides access to state-of-the-art structural biology technologies
available at the ESRF, EMBL, IBS and ILL. This includes new EM facilities
equipped with Titan Krios, and Glacios/Falcon III. Other facilities include the
ESRF synchrotron X-ray beamlines, high-field NMR at the IBS as well as the high-throughput
crystallization platform at the EMBL, mammalian and insect cell facilities, and
the biophysical platform. The lab has access to other synchrotrons: DLS, DESY,
SOLEIL, and SLS.
Applicants
should provide a motivation letter and a CV with contact information for two or
more referees.
For additional information please
visit:
Research Group
Website: https://noveltargets-palencia.com
Job Location: Grenoble, France
Position Type: Full-Time/Regular
Starting Contract: 24 Months (renewable)
Starting Date: Immediate to summer 2022
Contact:
andres.palencia@univ-grenoble-alpes.fr
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Dr. Andrés Palencia
National Institute of Health and Medical Research (Inserm)
Institute for Advanced Biosciences (IAB), Grenoble, Inserm–UGA–CNRS
Group Leader of Structural Biology of Novel Drug Targets in Human Diseases
Webpage: https://noveltargets-palencia.com
Phone: +33 (0) 476 54 95 75
ORCID: orcid.org/0000-0002-1805-319X
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Address:
Institute for Advanced Biosciences (IAB), Inserm–UGA–CNRS
Site Santé, Allée des Alpes,
38700 La Tronche, France
Email: andres.palencia@univ-grenoble-alpes.fr
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