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Job Description
New hires based in the US & Puerto Rico will be required
to demonstrate that they have been fully vaccinated for COVID-19 or qualify
for a medical or religious exemption or accommodation to this vaccination
requirement, subject to applicable law.
We
are seeking a creative, self-motivated structural biologist with exceptional
interpersonal and problem-solving skills to join the Computational and
Structural Chemistry (CSC) group in West Point, PA, USA. CSC is a diverse and
inclusive team of approximately 110 structural scientists, computational
chemists, informaticians, mass spectrometrists, biophysicists, and protein
scientists who employ state-of-the art capabilities to drive drug design. We
are an integral arm of both discovery and process chemistry and collaborate
seamlessly with teams around the globe to innovate and invent better
molecules faster.
We
are looking for an accomplished structural biologist who will support drug
discovery through the generation and analysis of atomic-resolution
macromolecular structures determined by X-ray crystallography or
single-particle Cryo-EM. The successful candidate will join our growing CSC
team and will be responsible for all aspects of the structural biology
process, from sample preparation and data collection through data processing,
structure determination, and effective communication of structural analyses
with key stakeholders.
The
structural biologist will be capable of working independently to design,
carry out, and interpret experiments required to test hypotheses and will
work closely with cross-functional drug discovery teams. In addition, the
successful candidate will establish productive and collaborative interactions
with other members of the global CSC department and leverage external
collaborations and exchange with the wider scientific community to keep our
team at the cutting edge of the structural biology and structure-based drug
discovery fields. The structural biologist is expected to foster and
contribute to a culture of diversity and inclusion where colleagues and
partners feel comfortable bringing their unique perspectives to work.
Consistently
cited as a great place to work, our company employs talented people who
discover, develop, manufacture, and market a wide range of vaccines and
medicines to address unmet medical needs. Each of us is joined by an
extraordinary sense of purpose — bringing our company’s finest achievements
to people worldwide.
Required Experience and Skills
- Ph.D. in
structural biology, biochemistry, or related field.
- Demonstrated
experience in X-ray crystallography or atomic resolution single-particle
Cryo-EM, including sample preparation, data collection, data processing
and structure determination and refinement.
- Proven track
record of outstanding scientific skills as exemplified by a strong
publication record.
- Demonstrated
potential to develop project management skills and identify/develop new
areas of scientific expertise in structural biology.
- Excellent
written and oral communication skills that enhance team-based progress.
- Ability to work
effectively and flexibly within timelines.
Preferred Experience and Skills
- One or more
years of successful post-doctoral experience in structural biology using
X-ray crystallography or cryo-EM.
- Experience with
sample preparation, data collection, data processing, and structure
determination using both X-ray crystallography and single-particle
Cryo-EM.
- Experience with
ligand co-crystallization and ligand soaking as well as crystal seeding
methodologies.
- Experience with
structure determination of small molecule protein complexes, membrane
proteins, and multi-subunit protein complexes.
- In-depth
knowledge of current biophysical and functional characterization methods
(e.g. SPR, BioNMR, thermal shift, ligand-binding, and calorimetric
assays) to guide construct design and optimization.
- Experience with
protein engineering, including the use of computational tools.
- Scientific
programming skills (e.g. Python) and interest in the application of
computational tools to answer structural biology questions.
We
are a research-driven biopharmaceutical company. Our mission is built on the
simple premise that if we “follow the science” that great medicines can make
a significant impact to our world. We believe that a research-driven
enterprise dedicated to world-class science can succeed by inventing medicine
and vaccine innovations that make a difference for patients across the
globe.
Who we are …
We
are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United
States and Canada and MSD everywhere else. For more than a century, we have
been inventing for life, bringing forward medicines and vaccines for many of
the world’s most challenging diseases. Today, our company continues to be at
the forefront of research to deliver innovative health solutions and advance
the prevention and treatment of diseases that threaten people and animals
around the world.
What we look for …
In
a world of rapid innovation, we seek brave Inventors who want to make an
Impact in all aspects of our business, enabling breakthroughs that will
affect generations to come. We encourage you to bring your disruptive
thinking, collaborative spirit and diverse perspective to our organization.
NOTICE FOR INTERNAL APPLICANTS
In
accordance with Managers’ Policy – Job Posting and Employee Placement,
all employees subject to this policy are required to have a minimum of twelve
(12) months of service in current position prior to applying for open
positions.
If
you have been offered a separation benefits package, but have not yet reached
your separation date and are offered a position within the salary and
geographical parameters as set forth in the Summary Plan Description (SPD) of
your separation package, then you are no longer eligible for your separation
benefits package. To discuss in more detail, please contact your HRBP or
Talent Acquisition Advisor.
Residents of Colorado
Click here to request this role’s pay range.
Current
Employees apply HERE
Current
Contingent Workers apply HERE
US and Puerto Rico Residents Only:
Our
company is committed to inclusion, ensuring that candidates can engage in a
hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the
application or hiring process.
For
more information about personal rights under Equal Employment Opportunity,
visit:
EEOC Poster
EEOC GINA Supplement
OFCCP EEO Supplement
Pay Transparency Nondiscrimination
We
are proud to be a company that embraces the value of bringing diverse,
talented, and committed people together. The fastest way to breakthrough
innovation is when diverse ideas come together in an inclusive environment.
We encourage our colleagues to respectfully challenge one another’s thinking
and approach problems collectively. We are an equal opportunity employer,
committed to fostering an inclusive and diverse workplace.
Search Firm Representatives Please Read
Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp &
Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from
search firms for employment opportunities. All CVs / resumes submitted by
search firms to any employee at our company without a valid written search
agreement in place for this position will be deemed the sole property of our
company. No fee will be paid in the event a candidate is hired by our
company as a result of an agency referral where no pre-existing agreement is
in place. Where agency agreements are in place, introductions are position
specific. Please, no phone calls or emails.
Employee Status:
Regular
Relocation:
Domestic/International
VISA Sponsorship:
Yes
Travel Requirements:
10%
Flexible Work Arrangements:
Shift:
Valid Driving License:
Hazardous Material(s):
Number of Openings:
1
Requisition ID:R154417
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