We are recruiting a postdoc for a computational structural biology project
that investigates the role of water networks at protein ligand interfaces
with a view towards ligand discovery. The position is available immediately
and NIH funded for 5 years.
We are looking for highly motivated candidates with curiosity and skills to
reveal hidden factors that contribute to protein-ligand binding and
leverage this information for ligand discovery. As this project integrates
experimental and computational data it will require both a solid background
in structural biology and significant computational skills for custom data
analysis and automation. The project is embedded into a dynamic lab that
has strong expertise in modulating protein conformational ensembles with
ligands and temperature (see references below).
The project is housed in the Department of Chemical Biology and Therapeutics
and Structural Biology
at
St. Jude Children’s Research Hospital. It builds on strong investments into
a world-class infrastructure in structural and chemical biology. This is an
exciting time to join us and build a career while living in an affordable
city. This postdoc position is NIH funded for 5 years.
Please direct your questions and application package including a cover
letter, current CV, and 3 letters of reference to: Dr. Marcus Fischer (
marcus.fischer@stjude.org).
Relevant papers include:
– Bradford et al. (2021). Temperature artifacts in protein structures
bias ligand-binding predictions. *Chemical Science*.
DOI: 10.1039/D1SC02751D
– Fischer (2021). Macromolecular room temperature crystallography. *Q
Rev Biophys* 54. E1
– Darby et al. (2019). Water Networks Can Determine the Affinity of
Ligand Binding to Proteins. *JACS* 141, 15818-26.
– Balius et al. (2017). Testing inhomogeneous solvation theory in
structure-based ligand discovery. *PNAS* E6839-46.
– Fischer et al. (2015). One crystal, two temperatures: cryocooling
penalties alter ligand binding to transient protein sites. *Chembiochem*
1560-64.
– Fischer et al. (2014). Incorporation of protein flexibility &
conformational energy penalties in docking screens to improve ligand
discovery. *Nature Chemistry* 6, 575-83.
More info at:
https://www.stjude.org/fischer
Minimum Education
– PhD in structural biology or related field
Minimum Experience
– High proficiency in coding incl Python
– Interest in dynamic aspects of structural biology including protein
flexibility and hydration
Optional requirements:
– Hands-on molecular biology and crystallography experience
https://postdoc-stjude.icims.com/jobs/8641/postdoctoral-research-assoc/job