Scientist in Protein Crystallography (PhD)
ZoBio (www.zobio.com) was founded in 2004 and is located in Leiden,
Netherlands. We offer innovative research services in the field of
small-molecule drug discovery to the pharmaceutical and biotech industries.
Our international team of 33 people covers four fields of expertise:
Protein Engineering and Production, Assay Development and Screening,
Structural Biology and Medicinal Chemistry.
We are currently looking to strengthen our team with an *X-ray
crystallographer* with a track record in protein crystallography and a
strong background in X-ray crystallographic data analysis. Experience
in building and refinement of protein-small-molecule complexes would be
extremely helpful.
You will support our clients’ drug discovery programs by solving
ligand-protein structures. You will work with minimal supervision but in a
highly collaborative environment within the Structural Biology team and
will effectively cooperate on a per-project basis with other research
groups at ZoBio. Your role will require working simultaneously on multiple
projects in a rapidly evolving environment. Team spirit and excellent
organization and communication skills are essential.
*TASKS & RESPONSIBILITIES*
– High-throughput crystallographic screening utilizing automation and
robotics
– High-throughput and -quality structure elucidation and interpretation
of biological macromolecules in complexes with small molecules of interest
– Utilization of X-ray crystallography pipelines with the aid of
computational structural biology tools to aid the efficient structure
elucidation of protein-ligand complexes
– Prepare presentations on the structural data for project teams and
clients
– Maintain up-to-date understanding of the current state of the field in
X-ray crystallography in relation to modern drug discovery challenges
*REQUIREMENTS*
– PhD in relevant field with experience in an industrial or
collaborative setting
– Hands-on experience with ligand modelling into electron density maps
and macromolecular model building and refinement in the context of
Structure-Based Drug Discovery campaigns
– Hands-on experience in solving challenging X-ray crystallography cases
(e.g.*ab initio* structure solution)
– Experience with computational structural biology tools such as ligand
docking, virtual screening, and molecular dynamics simulation would be
considered an advantage
– Experience in scripting and programming would be considered an
advantage
– Ability to work in a team in a result-driven, goal-oriented environment
It is fully expected that you will become a permanent and integral member
of the ZoBio team after an initial period of 12 months. Applicants at
either the Senior Scientist or Scientist level will be considered.
A tailored remuneration package will be proposed in line with individual
qualifications and experience. The position is immediately available; the
evaluation and assessment of candidates will run until the position is
filled.
Please send your CV, motivation letter and names of potential referees at hrm@zobio.com with the subject: “Scientist in Protein Crystallography”.