Hello Everyone,

We have two open positions in my group available immediately. Feel free to
get in touch with any questions or send along a CV & cover letter directly.

TJ Lane
Group Leader
Center for Free Electron Laser Science


Understanding how proteins move by through multi-crystal analysis
Postdoctoral Position
Center for Free Electron Laser Science (CFEL), Hamburg, Germany

We know proteins make use of long-range motions to perform the essential
functions of life: transmit signals, conduct chemistry, and mechanically
alter the environment, but how proteins accomplish these amazing tasks
remains unexplained at the atomic level. Experimentally measuring these
long-range motions at atomic detail has been a challenge. Recently, our
group had success in doing this for the main protease (Mpro) from
SARS-COV-2, the virus behind the COVID pandemic. Many datasets on COVID and
non-COVID proteins have been collected, but new methods are necessary to
investigate and extract information about protein motions in these data —
we seek a computational scientist to drive this work.

As the ideal candidate, you will have the following key attributes:

— A doctoral degree in physics, biophysics, computer science, or a related
field
— Excellent computational skills, including python and modern data science
methods
— Capabilities in computational crystallography (serial crystallography a
bonus but not required)
— Knowledge of the principles of protein structure and function
— The ability to drive your work independently and show initiative

And you will be excited to take on the following responsibilities:

— Writing software and scripting to perform data analysis on a daily basis
— Working with large, rich crystallographic datasets from synchrotrons and
XFELs

— Analysis/interpretation of experimental data and results
— Helping to foster an environment conducive to collaboration, learning,
growth, and fun

The position offers a chance to work at a world-leading center in the midst
of some of the pioneers of the x-ray laser field. CFEL, DESY, and the
broader Science City Bahrenfeld offer an interdisciplinary, collaborative,
welcoming, and energizing environment backed by excellently equipped labs,
computational and engineering support, and a mindset that no problem is too
big to tackle. You will bring your initiative and energy to use these
resources and this environment to do great science.

Available immediately is a two year contract with the possibility to extend
to three years, with a competitive salary and the opportunity to work and
live in the vibrant city of Hamburg, Germany.

For more details or to apply, write directly to TJ Lane and provide a CV
and short introduction or cover letter: thomas.lane@desy.de
Also see our website: pbio.cfel.de


Understanding enzyme catalysis by filming enzymes at atomic/fs resolution
Postdoctoral Position
Center for Free Electron Laser Science (CFEL), Hamburg, Germany

Enzymes are the best performing catalysts on Earth, yet the details of
their function — for example what role dynamics play or not in chemical
rearrangements — remain a source of debate. New x-ray free electron laser
(XFEL) technology allows us to directly image proteins at the time and
length-scales (atoms/fs) on which chemistry occurs, making it possible to
directly study enzyme catalyzed reactions via imaging. The photobiology
group led by TJ Lane at CFEL seeks a postdoctoral candidate to conduct this
work on naturally occurring and man-made photoenzyme systems.

As the ideal candidate, you will have the following key attributes:

— A doctoral degree in physics, chemistry, biochemistry, or a related field
— Excellent wet-lab skills, with knowledge of how to produce, purify, and
crystallize proteins
— A basic familiarity with serial femtosecond crystallography and XFELs
— Basic computational skills including unix-style environments,
python/matlab/similar
— The ability to drive your work independently and show initiative

And you will be excited to take on the following responsibilities:

— Design of experiments, including new hardware and software when necessary
— Organizing and leading teams of 2-20 people to conduct XFEL experiments
— Preparation of protein crystal samples and wet lab bio/chemistry
— Interpretation and analysis of experimental results
— Helping to foster an environment conducive to collaboration, learning,
growth, and fun

The position offers a chance to work at a world-leading center in the midst
of some of the pioneers of the x-ray laser field. CFEL, DESY, and the
broader Science City Bahrenfeld offer an interdisciplinary, collaborative,
welcoming, and energizing environment backed by excellently equipped labs,
computational and engineering support, and a mindset that no problem is too
big to tackle. You will bring your initiative and energy to use these
resources and this environment to do great science.

Available immediately is a two year contract with the possibility to extend
to three years, with a competitive salary and the opportunity to work and
live in the vibrant city of Hamburg, Germany.

For more details or to apply, write directly to TJ Lane and provide a CV

and short introduction or cover letter: thomas.lane@desy.de
Also see our website: pbio.cfel.de