For the expansion of our drug discovery team in Ghent (Belgium) we are currently looking for a Senior Scientist Structural Biology. Please send your CV and short motivation letter to veli-pekka.jaakola@confotherapeutics.com if you are interested.

Confo Therapeutics, a spin-off of VIB and VUB, is a drug discovery company built around a disruptive technology which enables it to address ‘undruggable’ -protein coupled receptors (GPCRs). The company is building a portfolio of transformative medicines in various disease areas. Confo has a unique technology which makes use of antibody fragments or “ConfoBodies(r)” to stabilize GPCRs in a particular conformation of interest as a superior starting point for protein structure determination. Recently, Confo secured an exclusive license to the Megabody(tm) technology. Megabodies enable to produce high resolution cryo-EM structures of membrane proteins, overcoming current protein size limitations and potential preferential orientation issues in the study of GPCRs via cryo-EM.

More information about Confo’s technology and strategy can be found on www.confotherapeutics.com.

Your responsibilities:

Biophysical, X-ray and EM experiments to produce GPCR structural biology results: provide experimental structural input and support to drive NCE projects to achieve milestone goals Working closely with medicinal chemists and biologist to help advance the project and technology platforms Supervising and coaching one or more research associates Leading the integrated discovery activities of projects as a core member of project teams Coordination and management of drug discovery projects: in a project leader role, you will be expected to maintain focus and provide direction to the team members with clear project plans and defined timelines, maintain productive relationships with project team members and communicate progress against goals in a multidisciplinary setting: chemistry, biology, pharmacology, and modeling

Your profile: PhD or equivalent experience in a related field, with at least 3 years of experience as post-doc or in a company Extensive technical skills in purification, sample preparation for and design and implementation of crystallization trials as well as demonstrated experience in crystal optimization techniques for membrane proteins

Demonstrated experience in sample preparation and optimization for cryo-EM studies on membrane proteins

Demonstrated expertise in data collection and interpretation of both X-ray crystallography and cryo-EM co-structure data to support NCE optimization

Experience with protein biophysical characterization ((F-)SEC, spectroscopic methods in detergent/lipid environment) and screening (thermal shift, NMR, SPR, fragment-like molecule screening) is a plus

Highly collaborative, self-motivated, team-oriented individual

Ability to work in a fast-paced, highly integrated team environment where accuracy, accountability and timeliness are essential

You are fluent in English and can communicate research results to the team and cross-functional stakeholders across the company

Our offer: A competitive compensation package with extensive benefits

An entrepreneurial and stimulating working environment in a growing and ambitious biotech company

Excellent career development opportunity, with exposure to all aspects of R&D in the company, with external collaborators and partners



Veli-Pekka Jaakola
Head of Structural Biology
Confo Therapeutics
Technologiepark 94
9052 Zwijnaarde
+32 471 80 01 56
veli-pekka.jaakola@confotherapeutics.com https://www.linkedin.com/in/vpjaakol