Dear All,

we have a post-Doc position available here at EMBL Grenoble shared between the
high throughput crystallisation team
(https://www.embl.fr/services/ht_crystallisation/index.html) and the
synchrotron team (https://www.embl.fr/research/unit/mccarthy/index.html) to
work with me on the ESRF beamline MASSIF-1 (http://www.esrf.eu/MASSIF1).
MASSIF-1 has pioneered fully automated data collection, including sample
location and decision making algorithms (see
https://doi.org/10.1107/S2059798318003728
http://dx.doi.org/10.1107/S1399004715011918
http://dx.doi.org/10.1107/S1600577515016604) This year will see two exciting
upgrades to the beamline – first, the ESRF will be coming back on-line after
completely re-building the accelerator (https://www.esrf.eu/about/upgrade) as
the worlds first high energy fourth generation synchrotron – ESRF-EBS – we
will be upgrading the beamline optics to maximise the capabilities of the new
source. Second, the experimental station of MASSIF-1 will be completely
refurbished to have a new diffractometer and the revolutionary crystal
mounting robot, CrystalDirect (http://dx.doi.org/10.1107/s2059798316000954
http://dx.doi.org/10.1107/s0907444912031459) will also be installed on the
beamline bringing automation all the way from pure protein to structure models
(see http://dx.doi.org/10.1063/1.5084627)

This is an exciting opportunity to be involved in the commissioning of an MX
beamline at the forefront of automation. This will be a highly collaborative
position working with the EMBL instrumentation, HTX and synchrotron teams, as
well as the ESRF, towards the design, construction and operation of the
upgraded MASSIF-1 beamline with a focus on expanding its capabilities to
support automated fragment screening and crystallography pipelines. You will
also contribute towards the development of new methods exploiting the unique
experimental opportunities provided by the integration of the CrystalDirect
technology in a beamline environment. You will also participate in research
projects involving fragment screening and development of chemical tools on
targets of biomedical relevance.

Please feel free to contact me, Josan Marquez (marquez@embl.fr) or Andrew
McCarthy (andrewmc@embl.fr) for informal inquiries – you will need to apply
here https://www.embl.de/jobs/searchjobs/index.php?nPostingID=1225&nPostingTargetID=2879&ID=QHPFK026203F3VBQB688N79SB
Closing date is the 12th October and interviews will be early November 2020.

Best wishes, Matthew.


Matthew Bowler
Synchrotron Crystallography Group
European Molecular Biology Laboratory
71 avenue des Martyrs

CS 90181 F-38042 Grenoble
France

Tel: +33 (0) 4.76.20.76.37
Fax: +33 (0) 4.76.20.71.99