Study Weekend Program... UP

New developments and future plans in the macromolecular refinement program - REFMAC

Garib N. Murshudov
Structural Biology Laboratory, University of York,
Heslington, York YO10 5YW, United Kingdom

Refmac is a macromolecular refinement program that uses some aspects of the Bayesian statistics and the maximum likelihood techniques. Refmac has an extensive built in dictionary of macromolecular building blocks. These include amino acids, DNA/RNA, sugars and many others. There are also tools available to create new dictionary entries. This talk will concentrate around the description of the dictionary, some of its features and tools available to handle new ligands. Some of the latest developments including Fisher's information matrix, refinement against data sets from twinned crystals and some future plans will also be highlighted.