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Iterative automated model-building and statistical density modification

T. Terwilliger
Los Alamos National Laboratory, Mail Stop M888,
Los Alamos, NM 87545 USA

Automated model-building beginning with an FFT-based search for helices and sheets and followed by pattern-based probabilistic identification of side chains has been successful in automated model building for maps with resolution as low as 3 Å. Model-building can be iteratively combined with statistical density modification to improve the quality and completeness of atomic models of macromolecules.