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[ccp4bb] Joint CCP-EM & CCP-BioSim Workshop on EM & MD @University of Leeds

We are proud to announce a pair of workshops held at the University of Leeds exploring the crossover between EM and MD.


(1) Computation for Biomolecular Cryo-Electron Microscopy and Tomography 
Sarah Harris (CCP-BioSim/Physics, Leeds), Albert Solernou (Physics/Leeds) and Ste Muench (Biological Sciences, Leeds), Tom Burnley (CCP-EM/STFC)

CCPBioSim-EM Workshop (14th July): Structural characterisation of proteins and protein complexes by cryo-EM and cryo-ET is now providing access to a wide range of macromolecular assemblies that were inaccessible by X-ray crystallography or NMR. Although EM analysis can provide information on different conformational states, it is still an averaging technique and therefore highly dynamic regions can be difficult to resolve. This workshop will explore the emerging computational techniques for achieving biological understanding from cryo-EM/ET images, and discuss areas most in need of further development.  Confirmed speakers include:

Christiane Berger-Schaffitzel, University of Bristol 
Christian Blau (Lindahl Group, Stockholm University) 
Max Bonomi (Vendruscolo Group), Univeristy of Cambridge 
Tom Burnley, CCP-EM / STFC 
Jose-Maria Carazo, National Center for Biotechnology, Spain 
Tristan Croll, Univeristy of Cambridge 
Sarah Harris, University of Leeds 
Agnel Joseph (Topf Group), Birkbeck 
Elena Orlova, Birkbeck 


(2) FFEA Workshop (13th July): This will be a hands-on workshop on the new software tool Fluctuating Finite Element Analysis (FFEA), which calculates dynamic trajectories for flexible biomolecules directly from cryo-EM/ET density maps. FFEA aims to provide an equivalent simulation tool for the EMDB as atomistic MD simulations have for the PDB. This approach uniquely uses volumetric meshes rather than atomistic co-ordinates as input such that it can model protein dynamics, protein-protein interactions, conformational switching between known configurational states and can be mapped back to atomistic co-ordinates, where these are available. This workshop is ideal for biomolecular simulators who would like to make full use of cryo-EM data in their modelling, or for experimentalists who would like to gain new theoretical insight into the dynamic behaviour of the structures they observe.


Best wishes,


Dr Tom Burnley, PhD
CCP-EM | @ccp_em | www.ccpem.ac.uk

Science and Technology Facilities Council (STFC)
The Research Complex At Harwell
Rutherford Appleton Laboratory, R92
OX11 0FA
01235 56 7871