+44 1925 603455
+44 1925 603825
Computational Science & Engineering Dept.,
STFC Daresbury Laboratory,
CSED home page, my Curriculum Vitae, and my
- I lead the CSED
Computational Biology team. Our primary interest is in classical molecular dynamics
simulations of proteins, in particular addressing very large systems.
- I also lead the core team of computational scientists working for
the CCP4 project at the Daresbury and Rutherford Appleton Laboratories.
We manage and distribute a large software suite
for protein structure solution via protein crystallography. See the extensive
CCP4 web pages for more information.
- I have research interests in the area of protein dynamics, particularly
with respect to the interpretation of X-ray diffraction data. See
- I also oversee the CSED
Chemical Database Service.
- There is a
short summary of some of my earlier research
See the full list.
- Johannes Kaestner, Hannes H Loeffler, Selene K Roberts, Marisa L Martin-Fernandez
and Martyn D Winn J. Struct. Biol., 167 117-128 (2009)
- "Ectodomain orientation, conformational plasticity and oligomerization of ErbB1 receptors
investigated by molecular dynamics"
- M.Vollmar, D. Schlieper, M. Winn, C. Buechner and G.Groth,
J. Biol. Chem., 284, 18228-18235 (2009)
- "Structure of the C14-rotor ring of the proton translocating chloroplast ATP synthase"
- D.J Rigden, R.M Keegan and M.D Winn Acta Cryst. D64 1288-1291 (2008)
- "Molecular Replacement using ab initio polyalanine models generated with ROSETTA"
reprint in PDF format
Copyright © International Union of Crystallography
- Stephen E.D. Webb, Selene K. Roberts, Sarah R. Needham, Christopher J.
Tynan, Daniel J. Rolfe, Martyn D. Winn, David T. Clarke, Roger Barraclough,
and Marisa L. Martin-Fernandez Biophys. J. 94, 803-819 (2008)
- "Single molecule imaging and FLIM show different structures for high and
low-affinity EGFRs in A431 cells"
R.M.Keegan and M.D.Winn,
Acta Cryst. D63, 447 - 457 (2007)
- "Automated search-model discovery and preparation for structure solution
by molecular replacement"
J. Synchrotron Rad. 10, 23---25 (2003)
- "An overview of the CCP4 project in Protein Crystallography: an example
of a collaborative project"
M.D.Winn, M.N.Isupov and G.N.Murshudov,
Acta Cryst. D57, 122 - 133 (2001).
- "Use of TLS parameters to model anisotropic displacements in
- Towards a Collaborative Computational Project for Electron cryo-Microscopy (CCPEM)
and bridging the gaps between structure determination methods, MRC, MR/J000825/1,
- BioMedBridges: Building data bridges and services between biological and medical
infrastructures in Europe, EU INFRA-2011-2.3.2, 2012-2016
- Ab initio protein modelling for automated X-ray crystal structure solution, BBSRC, 2010-2012
- Supra-molecular rules in signalling networks: A single molecule comparative
study in cells and tissues, BBSRC, 2009-2014
- CCP4: Low resolution complexes, handling of difficult data; empowering structural
biologists and supporting UK structural biology, BBSRC, 2008-2013
- MAX-INF2: European Macromolecular Crystallography Infrastructure Network 2,
EU FP6, 2004-2009
- TEMBLOR: The European Molecular Biology Linked Original Resources, EU, 01/01/02-31/12/04
- AUTOSTRUCT: Determination of Macromolecular Crystal Structures: Integrated,
Automated and User-Friendly Approaches, EU, 01/10/00-30/09/03
I was born in York
in 1966, and was brought up there.
I read Natural Sciences at Cambridge, followed by a D.Phil. in
theoretical chemistry from Oxford, completed in 1990. During the next
year, I held a postdoctoral position at Oxford funded by BP's Venture
Research, looking at electronic structure and conduction in disordered
materials. From 1991 to 1993, I continued this work as a research
fellow of the Royal Commission for the Exhibition of 1851. From 1993
to 1995, I was a Lise Meitner research fellow in the Institute for
Theoretical Physics at the
Technical University of Vienna, looking at
theory and simulations of hydrogenated diamond surfaces.
From 1995, I
have worked on the CCP4 project in protein crystallography at the
Daresbury Laboratory in Cheshire, UK, and from 2001 to 2009 I was the
leader of the core group of the CCP4 project. Major projects within
CCP4 included development of TLS refinement, a major re-write of the
core software libraries, and automation of structure solution through
molecular replacement. From 2007, I am group leader of the
computational biology group at Daresbury, working on biomolecular
simulation and other modelling of biological systems. In addition, I
manage the Chemical Database Service at Daresbury.
Martyn Winn: email@example.com
Last modified: Wed Jun 30 19:05:53 BST 2010