+44 1925 603455 (DL)
+44 1235 567865 (RcaH)
Scientific Computing Dept.,
STFC Daresbury Laboratory,
See also the
Computational Biology group pages, my Curriculum Vitae, and my
- I lead the SCD
Computational Biology group. Our primary interest is in computational structural
biology. The CCP4 and CCP-EM
teams develop software for two of the major experimental techniques. The biomolecular
simulation team pursue research using molecular dynamics on specific protein systems, and
support the CCPBioSim and
- I also lead Hartree Centre projects in
a number of bioinformatics areas, including algorithms for de novo transcriptome
- I have research interests in the area of protein dynamics, particularly
with respect to the interpretation of X-ray diffraction data. See
- There is a
short summary of some of my earlier research
See the full list.
- Ya-Wen Hsiao, Magnus Hedström, Valeria Losasso, Sebastian Metz, Jason Crain and Martyn Winn
(2018) "Cooperative Modes of Action of Antimicrobial Peptides Characterized with Atomistic Simulations: a Study on Cecropin B"
J. Phys. Chem. B, 122 5908-5921
- Keegan et al. (2018) "Recent developments in MrBUMP: Better search model preparation, graphical interaction with search models, and solution improvement and assessment"
Acta Cryst D74, 167-182
- CS Kim, MD Winn, V Sachdeva, KE Jordan (2017) "K-mer clustering algorithm using
a MapReduce framework: application to the parallelization of the Inchworm module of Trinity"
BMC Bioinformatics, 18, 467.
- Burnley, T., Palmer, C.M. and Winn, M.D. (2017) "Recent developments in the CCP-EM software suite"
Acta Cryst. D73 469-477. DOI: 10.1
- H.H.Loeffler and M.D.Winn, PROTEINS: Structure, Function, and Bioinformatics,
81, 1931-1943 (2013)
- "Ligand Binding and Dynamics of the Monomeric Epidermal Growth Factor Receptor Ectodomain"
- J. Bibby, R. M. Keegan, O. Mayans, M. D. Winn and D. J. Rigden,
Acta. Cryst. D68 , 1622-1631 (2012)
- "AMPLE: a cluster-and-truncate approach to solve the crystal structures
of small proteins using rapidly computed ab initio models"
- M. D. Winn et al.
Acta. Cryst. D67 , 235-242 (2011)
- "Overview of the CCP4 suite and current developments"
- M.Vollmar, D. Schlieper, M. Winn, C. Buechner and G.Groth,
J. Biol. Chem., 284, 18228-18235 (2009)
- "Structure of the C14-rotor ring of the proton translocating chloroplast ATP synthase"
M.D.Winn, M.N.Isupov and G.N.Murshudov,
Acta Cryst. D57, 122 - 133 (2001).
- "Use of TLS parameters to model anisotropic displacements in
- Validation Tools for Cryo-EM, Wellcome Trust Technology Development Grant 208398/Z/17/Z,
2018 - 2021. Total £1,168k. STFC £185k.
- Automated de novo building of protein models into electron microscopy maps, BBSRC BB/P000975/1,
2017-2020. Total £342k, STFC £22k.
- Collaborative Computational Project for Electron cryo-Microscopy (CCP-EM): Supporting the
software infrastructure for cryoEM techniques, MRC MR/N009614/1, 2016-2021
- West-Life: World-wide E-infrastructure for structural biology, EU EINFRA-9-2015, 2015 - 2018. Total €3981k, STFC €796k.
- High-performance computing in the search for the Tree of Life, STFC, ST/M000230/1, 2014-2015
- Towards a Collaborative Computational Project for Electron cryo-Microscopy (CCPEM)
and bridging the gaps between structure determination methods, MRC, MR/J000825/1,
- BioMedBridges: Building data bridges and services between biological and medical
infrastructures in Europe, EU INFRA-2011-2.3.2, 2012-2016
- Ab initio protein modelling for automated X-ray crystal structure solution, BBSRC, BB/H013652, 2010-2012
- Supra-molecular rules in signalling networks: A single molecule comparative
study in cells and tissues, BBSRC, BB/G006911, 2009-2014
- CCP4: Low resolution complexes, handling of difficult data; empowering structural
biologists and supporting UK structural biology, BBSRC, BB/F020805, 2008-2014
- MAX-INF2: European Macromolecular Crystallography Infrastructure Network 2,
EU FP6, 2004-2009
- TEMBLOR: The European Molecular Biology Linked Original Resources, EU, 01/01/02-31/12/04
- AUTOSTRUCT: Determination of Macromolecular Crystal Structures: Integrated,
Automated and User-Friendly Approaches, EU, 01/10/00-30/09/03
I was born in York
in 1966, and was brought up there.
I read Natural Sciences at Cambridge, followed by a D.Phil. in
theoretical chemistry from Oxford, completed in 1990. During the next
year, I held a postdoctoral position at Oxford funded by BP's Venture
Research, looking at electronic structure and conduction in disordered
materials. From 1991 to 1993, I continued this work as a research
fellow of the Royal Commission for the Exhibition of 1851. From 1993
to 1995, I was a Lise Meitner research fellow in the Institute for
Theoretical Physics at the
Technical University of Vienna, looking at
theory and simulations of hydrogenated diamond surfaces.
From 1995, I worked on the CCP4 project in protein crystallography at the
Daresbury Laboratory in Cheshire, UK, and from 2001 to 2009 I was the
leader of the core group of the CCP4 project. Major projects within
CCP4 included development of TLS refinement, a major re-write of the
core software libraries, and automation of structure solution through
molecular replacement. From 2007, I am group leader of the SCD
computational biology group, working on computational structural biology
and data intensive bioinformatics.
Martyn Winn: firstname.lastname@example.org
Last modified: Tue Aug 28 12:57:48 BST 2018