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[ccp4bb] PhD and postdoctoral position at CBI / IGBMC, Strasbourg



 

Dear all,

 

we have 2 open positions for a PhD candidate and a post-doctoral researcher to join the Klaholz group at the Centre for Integrative Biology, IGBMC, Illkirch, France http://igbmc.fr/Klaholz

 

We are studying the structure and function of protein complexes through integrated structural biology and notably by high resolution cryo-EM.

We are looking for 2 highly enthusiastic and motivated scientists with relevant expertise in structural biology of DNA/RNA-protein complexes, ideally with good experience in cryo electron microscopy. For further details please see below.

For those present at the 3D-EM Gordon conference please feel free to contact me directly.

 

With best regards,

 

Bruno Klaholz

 

 

 

 

Some recent publications:

 

- L. Andronov, J. Michalon, K. Ouararhni, I. Orlov, A. Hamiche, J.-L. Vonesch & B. P. Klaholz. 3DClusterViSu: 3D clustering analysis of super-resolution microscopy data by 3D Voronoi tessellations. Bioinformatics, 2018, Apr 4, in press. doi: http://dx.doi.org/10.1093/bioinformatics/bty200 and https://www.biorxiv.org/content/early/2017/06/07/146456.

- O. von Loeffelholz, G. Papai, R. Danev, A. G. Myasnikov, S. K. Natchiar, I. Hazemann & J.-F. Ménétret, & B. P. Klaholz. Volta phase plate data collection facilitates image processing and cryo-EM structure determination. J. Struct. Biol., 2018, 202, 191-199. doi: http://dx.doi.org/10.1016/j.jsb.2018.01.003.

- I. Orlov, R. Drillien, D. Spehner, M. Bergoin, A. Abd-Alla, B. P. Klaholz. Structural features of the Salivary gland hypertrophy virus of the tsetse fly revealed by cryo electron microscopy and tomography. Virology, 2018, 514, 165-169. http://dx.doi.org/10.1016/j.virol.2017.11.016.

- S. K. Natchiar, A. G. Myasnikov, H. Kratzat, I. Hazemann & B. P. Klaholz. Atomic model building and refinement into high-resolution cryo-EM maps. Protocol Exchange 2017 http://dx.doi.org/10.1038/protex.2017.122

- S. K. Natchiar, A. G. Myasnikov, H. Kratzat, I. Hazemann & B. P. Klaholz. Visualization of chemical modifications in the human 80S ribosome structure. Nature, 2017, 551, 472-477. doi: http://dx.doi.org/10.1038/nature24482. Epub 2017 Nov 15.

- O. von Loeffelholz, S. K. Natchiar, N. Djabeur, A. G. Myasnikov, H. Kratzat, J.-F. Ménétret, I. Hazemann & B. P. Klaholz. Focused classification and refinement in high-resolution cryo-EM structural analysis of ribosome complexes. Curr. Opin. Struct. Biol., 2017, 46, 140-148. doi: http://dx.doi.org/10.1016/j.sbi.2017.07.007.

- B. P. Klaholz. The ribosome holds the RNA Polymerase on Track in Bacteria. Trends Biochem Sci., 2017, 42, 686-689. doi: http://dx.doi.org/10.1016/j.tibs.2017.07.003.

- K. Mohideen-Abdul, K. Tazibt, M. Bourguet M, I. Hazemann, I. Lebars, M. Takacs, S. Cianférani, B. P. Klaholz, D. Moras & I. M. L. Billas. Importance of the Sequence-Directed DNA Shape for Specific Binding Site Recognition by the Estrogen-Related Receptor. Front. Endocrinol. 2017, 8, 140. doi: http://dx.doi.org/10.3389/fendo.2017.00140.

- I. Orlov, A. G. Myasnikov, L. Andronov, S. K. Natchiar, H. Khatter, B. Beinsteiner, J-F. Ménétret, I. Hazemann, K. Mohideen, K. Tazibt, R. Tabaroni, H. Kratzat, N. Djabeur, T. Bruxelles, F. Raivoniaina, L. di Pompeo, M. Torchy, I. Billas, A. Urzhumtsev & B. P. Klaholz. The integrative role of cryo electron microscopy in molecular and cellular structural biology. Biol Cell., 2017, 109, 81-93. doi: http://dx.doi.org/10.1111/boc.201600042.

-  A. G. Myasnikov, S. K. Natchiar, M. Nebout, I. Hazemann, V. Imbert, H. Khatter, J.-F. Peyron & B. P. Klaholz. Structure-function insights reveal the human ribosome as a cancer target for antibiotics. Nat Commun., 2016, 7, 12856. doi: http://dx.doi.org/10.1038/ncomms12856.

-  A. Simonetti, J.-F. Ménétret, F. Martin, A. G. Myasnikov, Q. Vicens, L. Prongidi-Fix, S. K. Natchiar, B. P. Klaholz & G. Eriani. Ribosomal 18S rRNA base pairs with mRNA during eukaryotic translation initiation. Nat Commun., 2016, 7, 12622. doi: http://dx.doi.org/10.1038/ncomms12622.

-  L. Andronov, I. Orlov, Y. Lutz, J-L. Vonesch & B. P. Klaholz. ClusterViSu, a method for clustering of protein complexes by Voronoi tessellation in super-resolution microscopy. Sci. Rep. 2016, 6, 24084. doi: http://dx.doi.org/10.1038/srep24084.

-  L. Andronov, Y. Lutz, J-L. Vonesch & B. P. Klaholz. SharpViSu: integrated analysis and segmentation of super-resolution microscopy data. Bioinformatics, 2016, 32, 2239-2241. doi: http://dx.doi.org/10.1093/bioinformatics/btw123.

-  B. P. Klaholz. Structure sorting of multiple macromolecular states in heterogeneous cryo-EM samples by 3D multivariate statistical analysis. Open Journal of Statistics, Special Issue on Multivariate Statistical Analysis, 2015, 5, 820-836. http://dx.doi.org/10.4236/ojs.2015.57081.

-  B. Beinsteiner, J. Michalon & B. P. Klaholz. IBiSS, a versatile and interactive tool for integrated sequence and 3D structure analysis of large macromolecular complexes. Bioinformatics, 2015, 31, 3339-3344. doi: http://dx.doi.org/10.1093/bioinformatics/btv347.

-  H. Khatter, A. G. Myasnikov, K. Natchiar & B. P. Klaholz. Structure of the human 80S ribosome. Nature, 2015, 520, 640-5. doi: 10.1038/nature14427. Epub 2015 Apr 22.

-  Z. A. Afonina, A. G. Myasnikov, V. A. Shirokov, B. P. Klaholz, A. S. Spirin. Conformation transitions of eukaryotic polyribosomes during multi-round translation. Nucleic Acids Res. 2015, 43, 618-28. doi: http://dx.doi.org/10.1093/nar/gku1270.

-  A. G. Myasnikov, Z. A. Afonina, J-F. Ménétret, V. A. Shirokov, A. S. Spirin & B. P. Klaholz. The molecular structure of the left-handed supra-molecular helix of eukaryotic polyribosomes. Nat Commun., 2014, 5, 5294. doi: http://dx.doi.org/10.1038/ncomms6294.

-  M. Maletta, I. Orlov, P. Roblin, Y. Beck, D. Moras, I. M. L. Billas & B. P. Klaholz. The palindromic DNA-bound USP/EcR nuclear receptor adopts an asymmetric organization with allosteric domain positioning. Nat Commun., 2014, 5, 4139. doi: http://dx.doi.org/10.1038/ncomms5139.

 

For ongoing projects and full publication list of the team see http://igbmc.fr/Klaholz

 

Our group is located at the Centre for Integrative Biology (CBI) at IGBMC, Illkirch/Strasbourg, France, which comprises cutting-edge cryo-EM facilities:

The CBI provides a leading-edge scientific and technological environment in integrated structural biology to address the structure and function of biological systems, notably on gene _expression_, from the atomic, molecular to the tissue scales. The CBI http://www.igbmc.fr/grandesstructures/cbi/, hosts the French and European Infrastructures for Integrated Structural Biology, FRISBI http://frisbi.eu/  and Instruct https://www.structuralbiology.eu/  which comprises advanced electron microscopy facilities equipped with cutting-edge instrumentation such as Titan Krios and Polara cryo electron microscopes, cryo Focused Ion Beam Scanning Electron Microscope (cryo-FIB/SEM) and super-resolution fluorescence microscopy http://frisbi.eu/centers/instruct-center-france-1-igbmc/cryo-electron-microscopy/. The Titan Krios microscope is equipped with Cs corrector, Falcon 3 camera, GIF energy filter, K2 camera and phase plate. In addition, the EM facility has a suite of associated equipments for sample preparation and dedicated computing resources for image processing and 3D reconstruction by single particle cryo-EM and cryo electron tomography (cryo-ET).

 

Applications should be sent via email to klaholz@igbmc.fr including CV, list of publications, names of 3 referees and motivation letter. The postdoctoral position remains open until filled.

 

For the PhD position there is the possibility for a fellowship through the doctoral school at the University of Strasbourg, 2 research topics are available:

https://thesisprojects.unistra.fr/publications/result_topic_individual/1528197632?session_scope=current_sessions&search_mode=search_by_keywords&search_criterium=keywords&search_value=klaholz&search_page=1&search_position=1&topic_id=340

https://thesisprojects.unistra.fr/publications/result_topic_individual/1528197632?session_scope=current_sessions&search_mode=search_by_keywords&search_criterium=keywords&search_value=billas&search_page=1&search_position=1&topic_id=347

Deadline is June 11th 2018. Please contact me in advance if you are interested.

 

 

 

###########################################################################

Bruno P. Klaholz

Centre for Integrative Biology

Department of Integrated Structural Biology
Institute of Genetics and of Molecular and Cellular Biology
IGBMC - UMR 7104 - U 1258

1, rue Laurent Fries
BP 10142
67404 ILLKIRCH CEDEX
FRANCE

Tel. from abroad: 0033.369.48.52.78
Tel. inside France:
03.69.48.52.78
websites:
http://igbmc.fr/Klaholz

http://www.igbmc.fr/grandesstructures/cbi/

http://frisbi.eu

 



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