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[ccp4bb] Job opportunity at Lonza Biologics, Cambridge, UK site

Dear all,

Please see below for an exciting structural bioinformatics job opportunity at Applied Protein Services, Lonza Biologics at our Cambrigde UK site.

Kind regards,

Sid Sridharan, PhD
Lead Scientist
Applied Protein Services

Lonza Biologics plc
Portway Building, Granta Park

Great Abington
Cambridge, CB21 6GS, UK

The job is posted in the link below, job ref R8148



  • Job Description Summary

    Here at Lonza we have a great opportunity available for a Senior Scientist to join Lonza's Applied Protein Services (APS) Bioinformatics team. This is a permanent position based out of our Cambridge facility.

    The Senior Scientist will work on multiple customer projects including antibody and protein engineering and design, antibody humanisation and deimmunisation and immunogenicity and protein risk assessments. In addition, the role will involve some system administration and programming to support the maintenance and development of multiple proprietary platforms.

    Key Responsibilities:

    • To perform computational antibody and protein engineering to design and/or modify potential biotherapeutics for customers
    • To perform in silico:
    • antibody humanisation and deimmunisation
    • immunogenicity risk assessments using Lonza’s proprietary EpibaseTM T-cell epitope prediction platform
    • developability risk assessments and antibody aggregation risk prediction using Lonza’s proprietary platforms
      • To perform expert sequence and structure based risk assessments
      • Program/script to support the development and maintenance of proprietary platforms and algorithms
      • Work in both Linux and Windows environments
      • To author high quality reports for clients and in-house development work
      • Share responsibility for maintenance and update of software, databases, systems and servers
      • To communicate project updates to internal and external clients


    What we need you to have:

    • PhD or equivalent experience in Bioinformatics/Structural Biology with a focus on computational protein engineering and modelling  , preferably with experience in industry
    • Demonstrate attention to detail and ensure that quality standards are maintained while delivering results