Dear CCP4 scientists,
This is a joint collaborative project between Israel and the University of Hamburg on the "mechanisms governing virulence and antibacterial properties of protein fibrils in infectious and aggregation disease"s.
The research methods include single particle cryoEM reconstruction, correlative light and electron microscopy, artificial membrane systems (supported lipid bilayers, liposomes), and live cell microscopy to study toxicity mechanisms of fibrils on bacteria and mammalian cells and within microbial biofilms.
Project leaders are Associate Prof. Meytal Landau, Technion-Israel Institute of Technology; Prof. Dr. rer. nat. Kay Grünewald, Heinrich-Pette-Institute, Leibniz Institute of Experimental Virology and Universität Hamburg, Fakultät für Mathematik, Informatik und Naturwissenschaften (MIN) and Centre for Structural Systems Biology (CSSB), DESY, Hamburg; Dr. Carolin Seuring, Head of the CryoEM Multi-User Facility, CSSB; Dr. Roland Thünauer, Head of the Advanced Light and Fluorescence Microscopy Facility, CSSB.
The research will be conducted at the CSSB on the Bahrenfeld Research Campus, Hamburg, Germany, also the home of the German synchrotron DESY, with occasional visits to Israel. CSSB harbors state-of-the-art multi-user facilities for protein production and characterization, high-throughput crystallization, advanced light microscopy and electron microscopy.
For more information: https://www.cssb-hamburg.de/facilities/index_eng.html
The position commences as soon as possible and is a fixed-term contract for a period of 2 years.
For further information on the Multi-User CryoEM and ALFM -facilities, please visit our website.
Meytal on behalf of the collaborative team
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