We seek to appoint a Research Associate in Structural Biology to work on the development of inhibitors of bacterial flap endonucleases (FEN) as potential new antimicrobial drugs. This is initially for a 16-month period to develop a new generation of anti-bacterial agents capable of targeting antibiotic resistant bacteria.
You will join a team during structure-based drug design to develop inhibitors of essential bacterial enzymes. Your role will be to prepare recombinant proteins, crystallise them and determine their X-ray structures. We welcome highly dedicated and enthusiastic candidates with the ability to develop their computer and wet laboratory skills. You will possess or have submitted a PhD degree in X-ray crystallography of protein molecules and have an interest in applying your expertise to structure-based drug development. Success in this post may lead to an opportunity to continue on the project subject to further funding being obtained.
FEN enzymes are involved in DNA replication and repair ( Nature Structural and Molecular Biology, 2016 :640-6. doi: 10.1038/nsmb.3241). We are using site-directed mutagenesis, crystallography and kinetic studies to assist in a structure-based drug design approach. We are housed within well-equipped laboratories with access to excellent core facilities with state-of-the-art equipment for e.g. biological mass spectrometry, Cryo-EM, X-ray crystallography, liquid handling robotics for high throughput screening & crystallization, a range of microscopy facilities, etc. You will join a multidisciplinary team representing a collaboration between The Sheffield Institute for Nucleic Acids (SInfoNiA) and The Flory Institute for Host-pathogen Interactions.
This post is fixed term for 16 months, with a start date of 1st March 2018 (or as soon as possible thereafter). Closing date 5th Feb.
Previous applicants need not apply. Formal applications to be made via the UoS web site.
https://www.sheffield.ac.uk/jobs. (reference UOS018387). or via: