A Postdoctoral position is available to work on a hot topic that links meiotic recombination and DNA topology control. The project, co-supervised by Profs Patrick Forterre and Claudine Mayer, aims to unveil the molecular mechanisms of double-strand breaks catalyzed by plant topoisomerase VI. The work will be performed in the team of Jacques Oberto at I2BC (Orsay, France) and the laboratory of Pedro Alzari at Institut Pasteur (Paris, France).
Various methods in structural biology (mainly X-ray crystallography but also cyo-EM), combined with enzymology and biophysics will be used to gain insights into the understanding of these fascinating nanomachines. The candidate will benefit from a large and rich scientific environment that extends to plant genetics as the project is part of an integrated program that includes collaboration with the team of Mathilde Grelon (INRA Versailles).
We seek a highly motivated candidate with a Ph.D. in the field of structural biology and with strong experience in protein biochemistry (production, purification and enzymatic assays). Experience in macromolecular crystallography is a plus, but not a requirement.
Remuneration: according to salary scale and experience. The position is open immediately and applications will be accepted until the position is filled.
Selected publications related to the position:
Vrielynck N, Chambon A, Vezon D, Pereira L, Chelysheva L, De Muyt A, Mézard C, Mayer C, Grelon M. A DNA topoisomerase VI-like complex initiates meiotic recombination.
Science. 2016 Feb 26;351(6276):939-43. doi:10.1126/science.aad5196. PubMed PMID: 26917763.
Gadelle D, Krupovic M, Raymann K, Mayer C, Forterre P. DNA topoisomerase VIII: a novel subfamily of type IIB topoisomerases encoded by free or integrated plasmids in Archaea and Bacteria.
Nucleic Acids Res. 2014 Jul;42(13):8578-91. doi: 10.1093/nar/gku568. Epub 2014 Jul 2. PubMed PMID: 24990376.