The Physical Biochemistry department is seeking an independent and highly motivated Molecular Biologist to join the Small Molecule Protein Sciences group (SMPS) at the Scientist I level. The SMPS is responsible for providing high quality protein reagents for small molecule targets to the Bioassays, Biophysics and the Structural biology groups.
The Physical Biochemistry department is seeking an independent and highly motivated Molecular Biologist to join the Small Molecule Protein Sciences group (SMPS) at the Scientist I level. The SMPS is responsible for providing high quality protein reagents for small molecule targets to the Bioassays, Biophysics and the Structural biology groups. The successful candidate must possess a broad set of skills, including Molecular Biology and _expression_ of proteins from bacterial and eukaryotic hosts. Special emphasis will be given to candidates with the ability to carry out rapid construct designs and purification. The selected individual will have the opportunity to work in cross-functional teams and should be able to clearly communicate their results and accomplishments to a broad audience at team meetings and in written reports.
• The selected candidate should exhibit expertise in Molecular Biology, including a variety of modern cloning approaches, construct design, sequence bioinformatics and tagging strategies.
• The ideal candidate would have experience expressing IMP (channels, transporters, GPCRs) _expression_ strategies from multiple hosts.
• The candidate should have demonstrated by publications or other means, an ability to carry out a variety of construct designs, _expression_ strategies and usage of multiple hosts. In addition, a sound knowledge of downstream small and large scale purification will be highly valued.
• Good experience in parallel, high throughput approaches to cloning and small scale _expression_ will be necessary.
• Working knowledge of Akta or equivalent instruments will be considered an asset.
• Bioinformatics programming (PERL, PYTHON) to decipher protein domains, sequence and structural alignments will be considered an asset.
• This candidate will also work with external CROs to coordinate molecular biology, _expression_ and purification handoffs.
• Must be adept at following protocols and should have the scientific experience to modify them when the situation arises.
• The candidate should have excellent verbal and written communication skills. Clear scientific presentation skills at project and team meetings are a must.
• Must be excellent in organization skills. The candidate is expected to document all aspects of the experiments performed and be able to conduct independent research to collect and archive all necessary information from the literature.
• Demonstration of innovative approaches to problem solving is essential.
Ph.D in Molecular Biology, Biochemistry or other suitable discipline.