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[ccp4bb] Postdoctoral fellowship in structure-guided drug discovery

Postdoctoral fellowship available in a collaborative structure-guided drug discovery project between my group and groups of Sharon Rossiter and Stewart Kirton at University of Hertfordshire, funded by the Hertfordshire Science Partnership Therapy Accelerator scheme.

Successful candidate will be part of a multidisciplinary team exploring novel inhibitors of a cancer drug target protein. The position offers access to the state of the art laboratory facilities at the University of Cambridge and the University of Hertfordshire, plus the opportunity to work at the dynamic industry/academia interface of the Stevenage BioScience Catalyst campus (http://www.stevenagecatalyst.com/). The postdoctoral fellow will develop and optimise biophysical methods for high-throughput screening of inhibitors, measurement of inhibitor-protein interactions, crystallographic elucidation of ligand-protein complexes and fragment-based approaches to discovering novel inhibitor scaffolds as a potential therapy for pancreatic cancer.

Applicants should possess (or about to obtain) a doctorate in biochemistry, chemistry, structural biology or a closely related subject. Experience in molecular cloning, protein expression, purification and characterisation, biophysical analysis of protein-ligand interactions and protein crystallography are essential for this post, previous experience in structure-guided drug discovery a definite advantage.

More details of the positions and on how to apply can be found through the link below and on the website of University of Hertfordshire (https://www.jobs.herts.ac.uk).

Informal enquiries can be sent to Dr Sharon Rossiter (s.rossiter@herts.ac.uk) or myself.




Marko Hyvonen
Department of Biochemistry, University of Cambridge
+44 (0)1223 766 044